Diphtheria toxin IgG levels in military and civilian blood donors in Rio de Janeiro, Brazil

Speranza, F.A.B.; Ishii, S.K.; Hirata, R.; Mattos-Guaraldi, A.L.; Milagres, L.G.

doi:10.1590/s0100-879x2010000100017

Cited by 2 publications

(4 citation statements)

References 7 publications

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“…One limitation of our study in army personnel is that it is similar to that of other studies (2,17). In Iran, military personnel are predominantly male and military service is mandatory for men.…”

Section: Discussionmentioning

confidence: 70%

“…Optical density was measured at 450/620 nm and antitoxin levels were determined by standard curves. According to manufacturer-recommended thresholds and the work of previous studies (13,17,21), the results were classified into 3 groups. The diphtheria groups were as follows: susceptibility (antitoxin level ＜0.1 IU/ mL), full protection (antitoxin level ＞1 IU/mL), and basic protection (antitoxin level ＞0.1 IU/mL and ＜1 IU/mL).…”

Section: Methodsmentioning

confidence: 99%

“…Some have studied special age groups (children, adults, or the elderly) (14)(15)(16) or special occupation groups (health care workers or military personnel) (17)(18)(19). Epidemiological necessity and the lack of studies in the region (to our knowledge) convinced us to conduct the first study of immunity to diphtheria and tetanus in army personnel and a sample population of adult civilians in Mashhad, Iran.…”

Section: Introductionmentioning

confidence: 99%

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Immunity to Diphtheria and Tetanus in Army Personnel and Adult Civilians in Mashhad, Iran

et al. 2017

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SUMMARY: This study aimed to investigate serologic immunity to diphtheria and tetanus in army personnel and a sample population of adult civilians in Mashhad, Iran. Army personnel (n ＝ 180) and civilians (n ＝ 83) who presented at Mashhad army hospital participated in this study. Diphtheria and tetanus antitoxin levels were determined by enzyme-linked immunosorbent assay. Approximately 77z and 94z of army personnel aged 18-34 years had at least basic protection against diphtheria (antitoxin level 0.1 IU/mL) and tetanus (antitoxin level ＞0.1 IU/mL), respectively. For civilians in this age group, the proportions were 76z for both diseases. Antitoxin levels waned with age. Thus, participants older than 50 years had lower immunity; this decrease in immunity was more pronounced for tetanus than for diphtheria in both army personnel and civilians. For both diseases, geometric mean antitoxin titers and the proportion of participants with at least basic protection were higher in subjects with a history of vaccination in the last 10 years (P ＜ 0.001), higher in men than women, and in army personnel than civilians in each age group. Young army personnel and civilians (18-34 years old) had adequate immunity to diphtheria and tetanus. However, the large number of susceptible older adults (＞50 years old) calls for improved booster vaccination protocols.

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Section: Discussionmentioning

confidence: 70%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immunity to Diphtheria and Tetanus in Army Personnel and Adult Civilians in Mashhad, Iran

et al. 2017

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“…Diphtheria toxin IgG levels in a group of Brazilian blood donors showed that a greater percentage (71%) of young military (18 to 30 years) was protected when compared to civilians (54%) of the same age group. These differences were possibly due to a higher rate of booster vaccination in young military group compared to civilians (1,10).…”

Section: Human Immunodeficiency Virus-1 (Hiv-1) Infection Leadsmentioning

confidence: 97%

Diphtheria Antibodies and T lymphocyte Counts in Patients Infected with HIV-1

Speranza¹,

Ishii²,

Thuler³

et al. 2012

Braz. J. Microbiol.

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We assessed the IgG levels anti-diphtheria (D-Ab) and T cell counts (CD4+ and CD8+) in HIV-1 infected subjects undergoing or not highly active antiretroviral therapy (HAART). Approximately 70% of all HIV-1 patients were unprotected against diphtheria. There were no differences in D-Ab according to CD4 counts.Untreated patients had higher D-Ab (geometric mean of 0.62 IU/ml) than HAART-patients (geometric mean of 0.39 IU/ml). The data indicated the necessity of keeping all HIV-1 patients up-to-date with their vaccination.

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Diphtheria toxin IgG levels in military and civilian blood donors in Rio de Janeiro, Brazil

Cited by 2 publications

References 7 publications

Immunity to Diphtheria and Tetanus in Army Personnel and Adult Civilians in Mashhad, Iran

Immunity to Diphtheria and Tetanus in Army Personnel and Adult Civilians in Mashhad, Iran

Diphtheria Antibodies and T lymphocyte Counts in Patients Infected with HIV-1

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