Diphtheria serology in adults in Central Java and East Java, Indonesia: the importance of continuous diphtheria vaccination

Sunarno, Sunarno; Asri, Febriyani; Subangkit,; Mursinah,; Herna,; Susanti, Nike; Kambang, Sariadji; Widoretno,; Febriyana, Dwi; Febrianti, Tati; Dian, Saraswati Ratih; Puspandari, Nelly

doi:10.4314/ahs.v21i3.23

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…The preliminary study data obtained indicates a high level of protection of the subjects from the indicated risk groups from diphtheria (99.5% (95% CI: 97.2–99.9%) of protected subjects among the examined cohort of pregnant women and 99.1% (95% CI: 97.8–99.8%) of protected subjects among the examined cohort of healthcare professionals) and tetanus (91.5% (95% CI: 86.7–95.0%) and 96.9% (95% CI: 94.9–98.3%) of protected subjects, respectively). This is comparable to the results obtained by researchers in other countries when testing for diphtheria and tetanus seroprevalence in the same risk groups ( 20 , 21 ), or among adults, regardless of their profession ( 22 , 23 ).…”

Section: Discussionsupporting

confidence: 89%

Diphtheria, tetanus, and pertussis immunity among healthcare professionals and pregnant women in the Moscow region, Russian federation: A preliminary cross-sectional study

Басов

Zhernov²,

Kashutina³

et al. 2023

Front. Pediatr.

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Despite more than 50 years of primary immunization against diphtheria, pertussis, and tetanus in Russia, complicated illnesses, including fatal ones, still occur. The goal of this preliminary cross-sectional study is to see how well pregnant women and healthcare workers are protected against diphtheria, pertussis, and tetanus. The required sample size (pregnant women and healthcare professionals, as well as pregnant women of two age categories) for this preliminary cross-sectional study was calculated using a confidence value of 0.95 and a probability of 0.05. The required number of participants in each group calculated sample size must be at least 59 people. In the Moscow region (Solnechnogorsk city, Russia), a cross-sectional study of pregnant patients and healthcare professionals interacting with children regularly as part of their job from numerous medical organizations was conducted in the year 2021 (n = 655). Antibodies to diphtheria, tetanus, and pertussis toxoids and microorganisms were measured using an enzyme-linked immunosorbent assay (ELISA). The STATISTICA and IBM SPSS Statistics 26.0 were used to process the study results statistically. Descriptive statistics methods, the Mann–Whitney U-test, discriminant analysis with the stepwise selection and analysis of ROC-curves were applied. IgG against diphtheria was found in 99.5% of pregnant women, tetanus in 91.5%, and pertussis in only 36.5%. According to the results of the discriminant analysis, the value of IgG to pertussis is linked to the value of IgA to pertussis and the gestational periods. Immunity to diphtheria was discovered in 99.1% of medical personnel, tetanus in 96.9%, and pertussis in 43.9%, no significant variations with age. When comparing the levels of immunity of pregnant women and healthcare professionals, it was shown that healthcare workers have greater levels of immunity against diphtheria and tetanus. The novel contribution of this study is that it will reveal the proportion of those vulnerable to pertussis, diphtheria, and tetanus among health workers and pregnant women in all age groups under the current national immunization program in Russia. Considering the data obtained from the preliminary cross-sectional study, we believe that it is necessary to conduct a full-scale study on a larger sample and, based on that, make certain changes to the national immunization program in Russia.

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Section: Discussionsupporting

confidence: 89%

Diphtheria, tetanus, and pertussis immunity among healthcare professionals and pregnant women in the Moscow region, Russian federation: A preliminary cross-sectional study

Басов

Zhernov²,

Kashutina³

et al. 2023

Front. Pediatr.

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“…Diphtheria, one of the VPDs, mainly includes respiratory diphtheria and cutaneous diphtheria, affecting respiratory mucosa and skin. The global case fatality rate is around 10%, and it keeps in severe cases ( 3 ). With diphtheria vaccination, the incidence of disease has decreased dramatically ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Surveillance for adverse events following immunization with DTaP-containing combination vaccines in Linping, China, 2019–2022

Chen,

Zhang,

et al. 2024

Front. Public Health

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BackgroundThe DTaP-Hib and DTaP-IPV/Hib combination vaccine can be used as a substitute for the diphtheria, tetanus, and acellular pertussis combined vaccine (DTaP). We aimed to evaluate the safety of multi-component vaccines containing DTaP by analyzing the reporting rates and characteristics of adverse events following immunization (AEFIs) in Linping District during the years 2019 to 2022.MethodsWe obtained data of AEFI and vaccination from the National AEFI Surveillance System of China and Zhejiang Municipal Immunization Information Management System, respectively, during 2019–2022 for a descriptive, epidemiological analysis.ResultsThe total number of AEFI reported following vaccinations with DTaP-containing combination vaccines was 802 in Linping District from 2019 to 2022. The overall reporting rates of AEFIs following DTaP, DTaP-Hib, and DTaP-IPV/Hib vaccinations were 445.72 (537 cases), 536.29 (45 cases), and 306.13 (220 cases) per 100,000 doses in Linping District from 2019 to 2022, respectively. Only one case of a serious AEFI following DTaP vaccination, with a reporting rate of 0.83 per 100,000 doses. The composition ratio of vaccine product-related reactions for DTaP, DTaP-Hib, and DTaP-IPV/Hib were 99.81, 97.78, and 100.00%, respectively. The composition ratio of coincidental events for DTaP and DTaP-Hib were 0.19 and 2.22%, respectively. The reporting rates of total AEFIs for DTaP-IPV/Hib were lower than for DTaP. The reporting rate of local induration for DTaP-Hib was lower than for DTaP, and the reporting rates of local redness & swelling and local induration for DTaP-IPV/Hib were both lower than for DTaP. DTaP-IPV/Hib had a higher proportion of AEFIs in first quarter compared to DTaP. The reporting rate after the second dose of DTaP-Hib was higher than that of DTaP, and the reporting rates of AEFIs after the first dose and third dose of DTaP-IPV/Hib were lower than DTaP.ConclusionThe reported AEFIs to multi-component vaccines containing DTaP components during 2019–2022 in Linping District were mainly mild vaccine reactions. DTaP-containing combination vaccines demonstrated a good safety profile.

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Peptide-ligand conjugate based immunotherapeutic approach for targeted dismissal of non-structural protein 1 of dengue virus: A novel therapeutic solution for mild and severe dengue infections

Srivastava,

Godara,

Jena

et al. 2024

International Journal of Biological Macromolecules

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Diphtheria serology in adults in Central Java and East Java, Indonesia: the importance of continuous diphtheria vaccination

Cited by 3 publications

References 17 publications

Diphtheria, tetanus, and pertussis immunity among healthcare professionals and pregnant women in the Moscow region, Russian federation: A preliminary cross-sectional study

Diphtheria, tetanus, and pertussis immunity among healthcare professionals and pregnant women in the Moscow region, Russian federation: A preliminary cross-sectional study

Surveillance for adverse events following immunization with DTaP-containing combination vaccines in Linping, China, 2019–2022

Peptide-ligand conjugate based immunotherapeutic approach for targeted dismissal of non-structural protein 1 of dengue virus: A novel therapeutic solution for mild and severe dengue infections

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