Diphtheria antitoxin in the blood of normal horses

Glenny, A. T.

doi:10.1002/path.1700280214

Cited by 10 publications

(3 citation statements)

References 6 publications

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“…The extent to which this state occurs must be dependent upon the opportunity of contact with suitable carriers. This is well illustrated by the history of natural immunity in horses described by Glenny (1925). In the early years of 60 0. past that the number of Schick negative children was much higher in crowded areas than in isolated communities.…”

Section: Unlmmunized Mothersmentioning

confidence: 90%

Concentration of Diphtheria Antitoxin in the Blood of Young Adults

Glenny

Barr

Billings

et al. 1955

J. Hyg.

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Summary1. The diphtheria antitoxin titres of several thousand samples of cord blood have been analysed with relation to the histories of the mothers.2. Among mothers without histories of diphtheria or of immunization those born in 1933 or later showed a higher degree of natural immunity.3. The distribution of antitoxin titres among mothers who had suffered from diphtheria was similar to the average distribution among the unimmunized.4. The differences in proportions with any antitoxin in different groups of unimmunized mothers were almost entirely made up of those with titres above 0·04 and below 1·0 unit per ml.5. Among the artificially immunized mothers there were many more with low titres, i.e. below 0·04, and a few more with high titres, i.e. over 1·0, than among the unimmunized.6. Mothers immunized between the ages of 9 and 14 with the peak at 11 or 12 years showed the highest immunity rate.7. The greatest number of high titres occurred among recovered cases subsequently immunized.

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Section: Unlmmunized Mothersmentioning

confidence: 90%

Concentration of Diphtheria Antitoxin in the Blood of Young Adults

Glenny

Barr

Billings

et al. 1955

J. Hyg.

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“…It is well known th a t the sim ultaneous exposure of an anim al to several antigens decreases the immune response to some of the antigens in the m ixture (1,2,11,12). It is, therefore, desirable to separate a complex antigenic m ixture into its components.…”

Section: Introductionmentioning

confidence: 99%

“…Because of the complexity of the medium in whicíi the larvae ihave to be grown (23) there m ight bs a dim inution of the immune response due to the presence of competing nonprotective immunogens.It is well known th a t the sim ultaneous exposure of an anim al to several antigens decreases the immune response to some of the antigens in the m ixture (1,2,11, 12). It is, therefore, desirable to separate a complex antigenic m ixture into its components.…”

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confidence: 99%

Ascaris suum: partial fractionation of metabolic antigens from "in vitro" cultured larvae

Guerrero

Silverman

1973

Rev. Soc. Bras. Med. Trop.

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INTRODU CTIONAscaris suum larval metabolic fluids nave been shown to be good protective antigens when injected into mice, prior to an infection (13,14,15). Because of the complexity of the medium in whicíi the larvae ihave to be grown (23) there m ight bs a dim inution of the immune response due to the presence of competing nonprotective immunogens.It is well known th a t the sim ultaneous exposure of an anim al to several antigens decreases the immune response to some of the antigens in the m ixture (1,2,11, 12). It is, therefore, desirable to separate a complex antigenic m ixture into its components. One of the preferred methods with the least biological damage to the antigens is fractionation on the basis of molecular size differences using filtration through a column of agarose gels. These are more rigid th a n m any other gels and have low compressibility so th a t a good flow rate and reproducible separation migih t bs insured (18).The present paper concerns attem pts to isolate the A. suum metabolic larval intigens from the culture medium using exclusion chrom atography. MATERIALS AND METHODSAnimais. One hundred and ten albino Swiss mice averaging 22.2 ± 1.5 gm in weight were divided into 11 groups of 10 anim ais ea ch .T h is stu d y w as p e rfo rm e d a t th e D e p a rtm e n t of Zoology, U n iv e rsity of Illin o is, U rb a n a , Illin o is, U .S .A ., u n d e r p a r tia l su p p o rt of g r a n t AI05910 from th e N a tio n a l I n s t it u t o of Allergy a n d In fe c tio u s Diseases. * C e n tro d e P e sq u isa s em F isio lo g ia e Im u n o lo g ia de H elm in to s, D e p a rta m e n to de M icrobiologia e Parasito lo g ia, E scola P a u lis ta de M ed icin a. São P a u lo . B rasil. ** D e p a rtm e n t o f Biology, U n iv ersity of New M exico, A lb u q u erq u e, New M exico. U .S .A . S u b m itte d to p u b lic a tio n on 6.25.73.

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