Diphenylhydantoin-lnduced Asterixis

Murphy, Martin J.

doi:10.1001/jama.1974.03230430030021

Cited by 12 publications

(2 citation statements)

References 9 publications

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“…Even though potentially hepatotoxic drugs are involved, it is neither associated with hepatic dysfunction nor metabolic abnormalities (8,9). Underlying brain lesions may also predispose to asterixis development.…”

Section: Discussionmentioning

confidence: 99%

Hyperammonemia in asterixis induced by carbamazepine: two case reports

Ambrosetto

Riva

Baruzzi

1984

Acta Neurologica Scandinavica

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Two patients developed asterixis while they were taking carbamazepine at "therapeutic" levels. The only laboratory abnormality was slight hyperammonemia. It occurred with normal hepatic function as a dose-related effect. In fact, the blood ammonia level decreased and asterixis ceased when carbamazepine was stopped or reduced in dosage. The relationship between asterixis and hyperammonemia during carbamazepine therapy is discussed.

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Section: Discussionmentioning

confidence: 99%

Hyperammonemia in asterixis induced by carbamazepine: two case reports

Ambrosetto

Riva

Baruzzi

1984

Acta Neurologica Scandinavica

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“…PHT may directly worsen myoclonic jerks in several epilepsy syndromes [182]. In patients with neurotoxic symptoms, non-epileptic myoclonus was also sporadically reported [182][183][184][185]. CBZ is the AED most frequently implicated in seizure worsening [181].…”

Section: Traditional Drugsmentioning

confidence: 99%

Adverse motor effects induced by antiepileptic drugs

Zaccara,

Cincotta,

Borgheresi

et al. 2004

Epileptic Disorders

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Cognitive effects of anti‐epileptic drugs (AEDs) have been already extensively reported. In contrast, motor disturbances, frequently induced by these drugs, have not received similar attention. We review subjective and objective adverse motor effects of traditional and new AEDs. We discuss the methodological issues caused by the heterogeneous sources of information on drug adverse effects (controlled clinical studies, open studies, and case reports). We describe specific disturbances (vestibulocerebellar, dyskinesias, parkinsonism, tics, myoclonus, and tremor) as the effects of different AEDs on distinct motor circuitries. Finally, we summarize the role of sophisticated technical studies which provide a valuable insight into the specific or subtle effects of AEDs on the central nervous system.

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Phenytoin-induced orofacial dyskinesia. A case report

1985

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A 56-year-old man with a small glioblastoma multiforme in the right parasagittal region developed orofacial dyskinesia and slight writhing movement of his hands during treatment with phenytoin and phenobarbitone. The serum concentration of phenytoin was within the therapeutic range. The involuntary movements subsided following the withdrawal of the drugs. Phenytoin-induced involuntary movements have not been described previously in a case with such a small parasaggital tumour treated with phenytoin at a serum concentration of therapeutic range.

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Diphenylhydantoin-lnduced Asterixis

Cited by 12 publications

References 9 publications

Hyperammonemia in asterixis induced by carbamazepine: two case reports

Hyperammonemia in asterixis induced by carbamazepine: two case reports

Adverse motor effects induced by antiepileptic drugs

Phenytoin-induced orofacial dyskinesia. A case report

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