Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice

Freitas, Andressa Sausen de; Funck, Vinícius Rafael; Rotta, Mariana dos Santos; Bohrer, Denise; Mörschbächer, Vanessa; Puntel, Robson Luiz; Nogueira, Cristina W.; Farina, Marcelo; Aschner, Michael; Rocha, João Batista Teixeira da

doi:10.1016/j.brainresbull.2008.11.001

Cited by 119 publications

(94 citation statements)

References 37 publications

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“…However, Se concentrations in muscle were significantly increased by dietary FO and FO + GTE in MeHg-exposed mice. Some studies have implied that Se and related components can ameliorate MeHg toxicity and enhance its excretion (de Freitas et al, 2009). In this study, exposure to MeHg significantly lowered muscle Se concentrations, but FO intake significantly restored muscle Se concentrations in these mice.…”

Section: Discussionmentioning

confidence: 50%

Simultaneous Effects of Green Tea Extracts and Fish Oil on Mercury Accumulation and Antioxidant Defenses in Methylmercury-exposed Adult Mice

Shirai

Yamashita

2013

FSTR

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Male mice (4 months old) were fed green tea extract-(GTE; 0.25% w/w) and/or fish oil-(FO; 5% w/w) containing diets with 8 ppm methylmercury (MeHg) chloride for 4 months to investigate the effects of simultaneous intakes on brain functions, antioxidant defenses against MeHg, and MeHg accumulation in tissues. In mouse maze tests, intake of GTE or FO significantly improved the learning ability of MeHg-exposed mice. GTE and FO also significantly decreased liver and brain catalase activities in MeHg-exposed mice. Total Hg concentrations in muscle were significantly lowered by dietary GTE and FO in the MeHgexposed group, though no remarkable differences were observed in the brain. These data indicate that simultaneous intake of GTE and FO effectively prevents MeHg-mediated oxidative stress and reduces the effects of Hg exposure with fish consumption.Keywords: fish oil, green tea, methylmercury, ascorbic acid, thiobarbituric acid reactive substances *To whom correspondence should be addressed. E-mail: nshinya@affrc.go.jp IntroductionFish contains several nutrients that are beneficial to human health. However, fish has been known to contain hazardous components such as methylmercury (MeHg), which has been linked to decreased neuropsychological function and increased risk of cardiovascular diseases (Choi et al., 2009;Virtanen et al., 2007). In contrast, n-3 polyunsaturated fatty acids (PUFA) contained in fish improve brain function (Guesnet et al., 2011;Mourek and Mourek, 2011) and reduce the risk of cardiovascular diseases (Cottin et al., 2011). Some reports indicate that dietary fat can influence oxidative DNA damage, nephrotoxicity, and steroidogenic enzyme activities after MeHg exposure (Grotto et al., 2011;Jin et al., 2008Jin et al., , 2009McVey et al., 2008). However, the human diet varies widely, and some reports have shown that foodstuffs other than seafood may also prevent MeHg toxicity and accumulation (Abdalla et al., 2010;Farina et al., 2005;Lee et al., 1999;Rowland et al., 1986;Sumathi et al., 2012). Therefore, daily fish consumption may alleviate relatively few health risks.In general, the Japanese drink a few cups of green tea every day, and often accompany sushi meals with green tea. Therefore, a close relationship exists between green tea and fish oil in the Japanese diet. Canuel et al. (2006) concluded that tea might accelerate the enterohepatic MeHg cycle and contribute to temporary MeHg bioamplification in the bloodstream. Green tea contains large quantities of polyphenols that have antioxidant effects and accelerate cadmium (Cd) excretion by forming chelates (Abib et al., 2011;Yu et al., 2007;Wang et al., 2012). Some studies indicate that green tea consumption reduces the risk of coronary heart disease (Bøhn et al., 2012;Chacko et al., 2010) and prevents agerelated neurodegeneration (Andrade and Assunção, 2012). Thus, these green tea polyphenol properties may be effective against MeHg toxicity.The aim of this study was to determine the interactive influence of fish oil and green tea on the effects o...

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Section: Discussionmentioning

confidence: 50%

Simultaneous Effects of Green Tea Extracts and Fish Oil on Mercury Accumulation and Antioxidant Defenses in Methylmercury-exposed Adult Mice

Shirai

Yamashita

2013

FSTR

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“…In other words, an environmental stressor can reveal genetic limitations which otherwise might not be associated with pathological consequences. In the case of AD, age-related metabolic changes undoubtedly enhance risk, and mercury's high affinity for selenoproteins and thiols makes redox and methylation metabolism especially prominent targets for its toxicity [10][11][12]24,139].…”

Section: A Mechanistic Model Of Mercury Toxicitymentioning

confidence: 99%

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

Mutter¹,

Curth

Naumann³

et al. 2010

JAD

147

113

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Abstract. Mercury is one of the most toxic substances known to humans. It has been introduced into the human environment and has also been widely used in medicine. Since circumstantial evidence exists that the pathology of Alzheimer's disease (AD) might be in part caused or exacerbated by inorganic mercury, we conducted a systematic review using a comprehensive search strategy. Studies were screened according to a pre-defined protocol. Two reviewers extracted relevant data independent of each other. One thousand and forty one references were scrutinized, and 106 studies fulfilled the inclusion criteria. Most studies were case control or comparative cohort studies. Thirty-two studies, out of 40 testing memory in individuals exposed to inorganic mercury, found significant memory deficits. Some autopsy studies found increased mercury levels in brain tissues of AD patients. Measurements of mercury levels in blood, urine, hair, nails, and cerebrospinal fluid were inconsistent. In vitro models showed that inorganic mercury reproduces all pathological changes seen in AD, and in animal models inorganic mercury produced changes that are similar to those seen in AD. Its high affinity for selenium and selenoproteins suggests that inorganic mercury may promote neurodegenerative disorders via disruption of redox regulation. Inorganic mercury may play a role as a co-factor in the development of AD. It may also increase the pathological influence of other metals. Our mechanistic model describes potential causal pathways. As the single most effective public health primary preventive measure, industrial, and medical usage of mercury should be eliminated as soon as possible.

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“…We have proposed that the selenol intermediate formed after reduction of diphenyl diselenide could react with MeHg to form a more excretable complex of the type CH 3 HgSePh, which considerably reduced the Hg burden in adult mice. 54 The potential formation of stable complex(es) between selenolate intermediate after reduction of ebselen by endogenous thiols could help to explain the protective effect of ebselen administration in different regimen of MeHg exposure in rats and mice. 55 In view of the reduction of mercury deposition after simultaneous exposure to diphenyl diselenide and protective effects of ebselen against MeHg, we suppose that selenolate intermediates (formed after the reaction of these organoselenium compounds with endogenous thiols) could increase the excretion of mercury.…”

Section: Mercurymentioning

confidence: 99%

Diphenyl diselenide a janus-faced molecule

Nogueira

Rocha

2010

J. Braz. Chem. Soc.

200

106

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Este artigo de revisão aborda uma reflexão sobre o potencial terapêutico ou tóxico de compostos orgânicos de selênio, dando particular ênfase ao disseleneto de difenila e alguns dos seus análogos estruturais. Algumas características moleculares relacionadas com a toxicidade e farmacologia do disseleneto de difenila in vitro e in vivo são abordadas. Os artigos revisados, que abordam experimentos in vivo, indicam que a interação do disseleneto de difenila com tióis pode determinar seu potencial farmacológico ou toxicológico. Além disso, uma limitada ativação da rota de toxicidade, isto é, a oxidação controlada de moléculas de alto peso molecular, que contém grupos tióis, poderia contribuir para os efeitos farmacológicos do disseleneto de difenila. Concluise que a síntese de compostos orgânicos de selênio deve ser direcionada para o desenvolvimento de novos disselenetos de diorganoila que possam interagir com alvos moleculares específicos.In this review, we summarized the potential role of synthetic organoseleno compounds as therapeutic or toxic agents, giving emphasis almost exclusively to diphenyl diselenide, the simplest of the diaryl diselenides, and some of its analogs. We presented the main molecular aspects related to the in vitro toxicity and pharmacology of diphenyl diselenide and also provided in vivo data indicating that the interaction of diphenyl diselenide with thiols can dictate either its toxicological or pharmacological property. The papers covered in this review indicate that a limited activation of the "toxic pathway", i.e., a controlled oxidation of specific high molecular weight thiol-containing molecules could contribute to the pharmacological effects of diphenyl diselenide. In conclusion, this review reinforces the necessity of developing new diorganoyl diselenides that could interact with specific molecular targets.

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Diphenyl diselenide, a simple organoselenium compound, decreases methylmercury-induced cerebral, hepatic and renal oxidative stress and mercury deposition in adult mice

Cited by 119 publications

References 37 publications

Simultaneous Effects of Green Tea Extracts and Fish Oil on Mercury Accumulation and Antioxidant Defenses in Methylmercury-exposed Adult Mice

Simultaneous Effects of Green Tea Extracts and Fish Oil on Mercury Accumulation and Antioxidant Defenses in Methylmercury-exposed Adult Mice

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

Diphenyl diselenide a janus-faced molecule

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