Diphencyprone in the treatment of alopecia areata

Abstract

27 patients suffering from either extensive alopecia areata (n = 5) or alopecia totalis (n = 22) were treated topically with diphencyprone, a new potent contact allergen. The duration of treatment ranged from 4 to 17 months. Unilateral induction of hair growth after unilateral treatment was observed in 23 patients. A continuous response after continuous treatment has been observed so far in 18 of these patients. Thus, diphencyprone was found to be as effective as DNCB or squaric acid dibutylester in the treatment of alopecia areata. Unlike DNCB, diphencyprone is not mutagenic in the Ames test. Compared with squaric acid dibutylester, diphencyprone is more stable and thus more suitable for storage when dissolved in acetone. Further investigative evaluation of diphencyprone may show whether this drug is suitable for a more general use in the treatment of severe forms of alopecia areata.

Local treatments for alopecia areata: an update

“…Sun exposure is better to be avoided during the presence of the topical immunotherapy substance over the skin. (19) If there was no response (hair regrowth) after six months, the patient is considered as non-responder to DPCP and the therapy must be discontinued. Long time is required as 12-18 months of therapy length before confirming the result of DPCP as good response may occur very late after years.…”