Diphasic Seasonal Variation of the Serum Protein-Bound Iodine Level

Watanabe, Genichi; Uematsu, Minoru; Horii, Kin-ichi

doi:10.1210/jcem-23-4-383

Cited by 25 publications

(7 citation statements)

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“…Although haemoconcentration is known to occur in colder weather (Wilson, 1966), the haematocrit changes in the subjects studied by Thompson and Kight (1963) and by Watanabe et al (1963) were insufficient to account for the variations in serum PBI which they observed.…”

Section: Labourmentioning

confidence: 88%

“…Falls have been recorded by Ingbar and Bass (1957) and by Watanabe et al (1963). Gottschalk and Riggs (1952) reported that the serum PBI was unaffected by life in the Arctic.…”

Section: Cold Climatic Conditionsmentioning

confidence: 90%

“…In the Eskimo, upper and lower limits for the serum PBI are 1 ,tg/l00 ml above those for Caucasians (Gottschalk and Riggs, 1952;Davies and Hanson, 1965), and in Marshall Islanders the serum PBI level averages 2 ,ug/100 ml above that of Caucasians, probably because an abnormal iodoprotein is present in the blood (Rall and Conard, 1966 The serum PBI has been consistently reported to be low in hot weather compared with the serum PBI levels of the same subjects in temperate weather (Thompson and Kight, 1963;Watanabe, Uematsu, and Horii, 1963;Duruisseau, 1965). Although haemoconcentration is known to occur in colder weather (Wilson, 1966), the haematocrit changes in the subjects studied by Thompson and Kight (1963) and by Watanabe et al (1963) were insufficient to account for the variations in serum PBI which they observed.…”

Section: Labourmentioning

confidence: 99%

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The interpretation of the serum protein-bound iodine: A review

Acland

1971

J Clin Pathol

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Section: Labourmentioning

confidence: 88%

“…Falls have been recorded by Ingbar and Bass (1957) and by Watanabe et al (1963). Gottschalk and Riggs (1952) reported that the serum PBI was unaffected by life in the Arctic.…”

Section: Cold Climatic Conditionsmentioning

confidence: 90%

Section: Labourmentioning

confidence: 99%

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The interpretation of the serum protein-bound iodine: A review

Acland

1971

J Clin Pathol

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“…Although a seasonal variation in serum thyroid hormone concentration in normal adult has been demonstrated by several authors (Osiba, 1957;Watanabe et al, 1963;Du Ruisseau, 1965;Rastogi and Sawhney, 1976;Nagata et al, 1976;Smals et al, 1977), a concomitant change in serum thyroid stimulating hormone (TSH) level has not been shown (Rastogi and Sawhney, 1976;Nagata et al, 1976;Hedstrand and Wide, 1973). Recent studies at our laboratory also failed to find winterrelated changes in the basal concentration of TSH or in the TSH response to thyrotropinreleasing hormone (TRH) desite an elevation in serum triiodothyronine (T3) concentration (Konno, 1978).…”

mentioning

confidence: 95%

Reciprocal changes in serum concentrations of triiodothyronine and reverse triiodothyronine between summer and winter in normal adult men.

Koono

1980

Endocrinol Japon

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Serum concentrations of thyroxine (T4), 3, 5, 3'-triiodothyronine (T3), 3, 3', 5'-triiodothyronine (reverse T3, rT3), thyronine-binding globulin (TBG), thyroid stimulating hormone (TSH) and cortisol in summer and in winter were compared in carefully selected normal adult men (aged 30-49 yr); 107 people from Sapporo (58 in summer and 49 in winter) and 15 hospital workers.A modest but significantly higher serum T3 concentration was recorded in winter than in summer, while T4, TSH, TBG and cortisol levels were similar in both seasons. Serum rT3 concentration in the Sapporo subjects was slightly higher in summer than in winter but difference was not statistically significant.However, a paired analysis of rT3 concentration in the hospital workers had significantly higher levels in summer than in winter, showed a significant rise in the rT3 to T3 ratio in summer compared to winter. These results were not likely to be due to changes in TBG, cortisol and hematocrit values. The present findings and our previous report on a similar TSH response to thyrotropin-releasing hormone in summer and in winter, indicate that the changes in thyroid hormone metabolism rather than in thyroidal secretion would, at least partly, be responsible for the reciprocal alteration in T3 and rT3 concentrations.

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“…Watanabe, Uematsu & Horii (1963) in Japan found that PBI decreased in severe and increased in mild weather. On the other hand, increased PBI values have been reported after cold exposure (Gottshalk & Riggs, 1952;Thompson & Knight, 1963;Du Ruisseau, 1965).…”

Section: Resultsmentioning

confidence: 99%

Reduced Thyroid Activity in Jamaicans

Harland¹,

Richards²,

Goldberg³

1971

Journal of Endocrinology

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The results presented demonstrate reduced thyroid activity in euthyroid Jamaicans. In 15 subjects, thyroid clearance of 131I was 13\m=.\0\ m=+-\ 8\m=. \8(s.d.) ml/min, and renal clearance was 20\m=.\6\ m=+-\9\m=.\7 ml/min. In 205 healthy volunteers the 24 h 131I thyroid uptake averaged 13\m=.\8 % and in 60\m=.\9% the uptake was less than 10 % of the dose. Urinary excretion of 131I was correspondingly high. However, excretion of stable iodine in urine averaged only 62\ m=. \ 0\ g=m\ g/ day. Thyroid secretion rate (TSR) calculated in a group of subjects with complete collection of urine was 12\m=.\0\ g=m\gI/day in women and 11\m=.\4\g=m\gI/day in men. Protein-bound iodine (PBI) values in 50 subjects were 5\ m=. \ 9\ m=+-\ 1\ m=. \ 3\ g=m\ g/ 100 ml. Uptake of tri-iodothyronine by red blood cells also gave low values. The apparent discrepancy between low TSR and normal PBI is discussed. These findings, together with other reported values, indicate reduced thyroid activity in the tropics. It is argued that reduced metabolism is probably secondary to lower thyroid activity.

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Diphasic Seasonal Variation of the Serum Protein-Bound Iodine Level

Cited by 25 publications

References 0 publications

The interpretation of the serum protein-bound iodine: A review

The interpretation of the serum protein-bound iodine: A review

Reciprocal changes in serum concentrations of triiodothyronine and reverse triiodothyronine between summer and winter in normal adult men.

Reduced Thyroid Activity in Jamaicans

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