Dipeptidyl peptidase IV (DPP IV/CD26) staining predicts distant metastasis of ‘benign’ thyroid tumor

Abstract

Because follicular thyroid carcinoma is extremely difficult to diagnose, several cases were encountered which have been rediagnosed as carcinoma due to distant metastasis. In the search for a method of correctly diagnosing 'benign' thyroid tumor, dipeptidyl peptidase (DPP) IV immunostaining was applied to 10 cases whose diagnoses had been corrected to follicular thyroid carcinoma because of distant metastases. The positive rate of immunostaining using paraffin sections in the rediagnosed follicular thyroid carcinoma group (7/10) was much higher than that of the control group (1/29), which consisted of 15 cases of follicular thyroid adenoma and 14 cases of nodular hyperplasia. These results suggested that pre- or postoperative DPP IV staining is useful for predicting distant metastasis of 'benign' thyroid tumor.

Regulation of Fibroblast Migration on Collagenous Matrix by a Cell Surface Peptidase Complex

“…Other studies also demonstrated the involvement of seprase and matrix metalloproteases in breast cancer cell invasion (32,33). A retrospective study on follicular thyroid carcinoma supports the proposal that DPPIV could be a marker for cell invasiveness (34). Here we show that the seprase-DPPIV complex is also a marker for connective tissue cell invasiveness and the invadopodia of migrating fibroblasts.…”

CD26 Overexpression Is Associated with Prolonged Survival and Enhanced Chemosensitivity in Malignant Pleural Mesothelioma

“…On the contrary, inhibition of CD26 in renal cell carcinoma decreased tumor growth and reduced binding of the cancer cells to fibronectin and collagen (15). Moreover, clinical studies in thyroid cancer, GIST, and T-cell non-Hodgkin lymphoma/leukemias suggested that CD26 expression was associated with distant metastasis, recurrence after resection, or poor survival (16,18,44). The multifunctional roles of CD26 may account for its varied roles in different cancers (11).…”

Distinct Gene Expression–Defined Classes of Gastrointestinal Stromal Tumor

“…33 It is expressed on a wide variety of cell lineages including T lymphocytes, endothelial and epithelial 34,35 Differential diagnosis of follicular carcinoma of the thyroid from follicular adenoma has been one of the most difficult tasks for surgical pathologists. CD26 is a 110-kDa cell membrane glycoprotein that belongs to the serine protease family (EC 3.4.14.5).…”