Dipeptidyl Peptidase IV as a Muscle Myokine

Kluess, Heidi A.

doi:10.3389/fphys.2020.00148

Cited by 7 publications

(8 citation statements)

References 45 publications

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“…In recent years, research has shown that skeletal muscles release DDP-4 as a myokine and could regulate muscular blood flow. 136 DPP-4 inhibitors inhibited loss of muscle mass in older patients with type 2 diabetes. 137 Furthermore, compared with SU drugs, DPP-4 inhibitors inhibited the progression of loss of muscle mass and sarcopenia.…”

Section: Incretin Modulatorsmentioning

confidence: 98%

Skeletal muscle as a treatment target for older adults with diabetes mellitus: The importance of a multimodal intervention based on functional category

Omura

Araki

2022

Geriatrics Gerontology Int

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Although the lifespan of people with diabetes has increased in many countries, the age-related increase in comorbidities (sarcopenia, frailty and disabilities) and diabetic complications has become a major issue. Diabetes accelerates the aging of skeletal muscles and blood vessels through mechanisms, such as increased oxidative stress, chronic inflammation, insulin resistance, mitochondrial dysfunction, genetic polymorphism (fat mass and obesity-associated genes) and accumulation of advanced glycation end-products. Diabetes is associated with early onset, and progression of muscle weakness and sarcopenia, thus resulting in diminished daily life function. The type and duration of diabetes, insulin section/resistance, hyperglycemia, diabetic neuropathy, malnutrition and low physical activity might affect muscular loss and weakness. To prevent the decline in daily activities in older adults with diabetes, resistance training or multicomponent exercise should be recommended. To maintain muscle function, optimal energy and sufficient protein intake are necessary. Although no specific drug enhances muscle mass and function, antidiabetic drugs that increase insulin sensitivity or secretion could be candidates for improvement of sarcopenia. The goals of glycemic control for older patients are determined based on three functional categories through an assessment of cognitive function and activities of daily living, and the presence or absence of medications that pose a hypoglycemic risk. As these functional categories are associated with muscle weakness, frailty and mortality risk, providing multimodal interventions (exercise, nutrition, social network or support and optimal medical treatment) is important, starting at the category II stage for maintenance or improvement in daily life functions. Geriatr Gerontol Int 2022; 22: 110-120.

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Section: Incretin Modulatorsmentioning

confidence: 98%

Skeletal muscle as a treatment target for older adults with diabetes mellitus: The importance of a multimodal intervention based on functional category

Omura

Araki

2022

Geriatrics Gerontology Int

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“…In addition to what we have summarized above, with the development of biotechnology, more and more myokines have been discovered, such as Apelin ( 116 ), Chitinase-3-like protein ( 117 ), Follistatin-like 1 ( 118 ), Dipeptidyl Peptidase IV ( 119 ), MG53 ( 120 ) and METRNL ( 121 ), which they also play a key role in maintaining the human homeostasis of the body. Further studies are needed to determine whether they are related to DN and, if so, how Table 1 .…”

Section: Myokines and Dnmentioning

confidence: 99%

Myokines: Novel therapeutic targets for diabetic nephropathy

Yang

Luo²,

Yang³

et al. 2022

Front. Endocrinol.

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With the increasing incidence of diabetic nephropathy (DN), there is an urgent need to find effective DN preventive and therapeutic modalities. It is widely believed that effective exercise is good for health. However, the beneficial role of exercise in kidney disease, especially in DN, and the underlying molecular mechanisms have rarely been reported. Muscle is not only an important motor organ but also an important endocrine organ, secreting a group of proteins called “myokines” into the blood circulation. Circulating myokines then move to various target organs to play different biological roles. In this review, we summarize the currently known myokines and the progress in research relating them to DN and discuss its potential as a therapeutic target for DN.

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“…Skeletal muscles (SM) comprise the largest organ in the body, and thus, process the largest amounts of administered drugs [ 62 ]. Furthermore, muscle has recently been reported to release DPP-4 [ 63 ]. SM cell cultures were observed to release DPP-4 during differentiation [ 64 ], and DPP-4 activity in the bathing medium from intact SM was found to be enhanced by whey protein in situ [ 65 ].…”

Section: Dpp-4 Inhibition and Skeletal Muscle Functionmentioning

confidence: 99%

A Comprehensive Review and Perspective on Natural Sources as Dipeptidyl Peptidase-4 Inhibitors for Management of Diabetes

et al. 2021

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Type 2 diabetes mellitus (T2DM) is an increasing global public health problem, and its prevalence is expected to rise in coming decades. Dipeptidyl peptidase-4 (DPP-4) is a therapeutic target for the management of T2DM, and its inhibitors prevent the degradation of glucose-dependent insulinotropic peptide and glucagon-like peptide 1, and thus, maintain their endogenous levels and lower blood glucose levels. Various medicinal plant extracts and isolated bioactive compounds exhibit DPP-4 inhibitory activity. In this review, we discussed different natural sources that have been shown to have anti-diabetic efficacy with a particular emphasis on DPP-4 inhibition. Furthermore, the effect of DPP-4 inhibition on pancreatic beta cell function, skeletal muscle function, and the glucose-lowering mechanisms were also discussed. We believe that scientists looking for novel compounds with therapeutic promise against T2DM will be able to develop antidiabetic drugs using these natural sources.

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Dipeptidyl Peptidase IV as a Muscle Myokine

Cited by 7 publications

References 45 publications

Skeletal muscle as a treatment target for older adults with diabetes mellitus: The importance of a multimodal intervention based on functional category

Skeletal muscle as a treatment target for older adults with diabetes mellitus: The importance of a multimodal intervention based on functional category

Myokines: Novel therapeutic targets for diabetic nephropathy

A Comprehensive Review and Perspective on Natural Sources as Dipeptidyl Peptidase-4 Inhibitors for Management of Diabetes

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