Dipeptidyl Peptidase 4 mediated Caspase-8 Affects Cognitive Impairment in Mice with Alzheimer's Disease
XinYi Wang,
Li Chen,
Ke Wang
et al.
Abstract:To investigate the effect of dipeptidyl peptidase 4 (DPP4) on cognitive impairment in Alzheimer's disease (AD), the present study used seven-week-old male C57BL/6J and DPP4 knockout mice. The AD model was induced by microinjection of Aβ25−35 into the lateral ventricle. Morris water maze test showed that DPP4 knockout significantly improved the spatial learning and memory abilitoes of AD mice. Western blot results showed that DPP4 knockout increased the expression levels of BDNF, CREB and Bcl-2 in the hippocamp… Show more
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