Dipeptide‐functionalized MIL‐101(Fe) as efficient material for ibuprofen delivery

Abstract

Two derivatives of a dipeptide-functionalized metal-organic framework were synthesized through isocyanide-based multi-component reactions from amine-containing MIL-101(Fe). The functionalized materials were characterized by means of Fourier transform infrared spectroscopy, X-ray diffraction Brunauer-Emmett-Teller measurements, thermogravimetric analysis, elemental analysis and scanning electron microscopy. The performances of these functionalized MIL-101(Fe) materials with different functions were evaluated for ibuprofen delivery during six days, showing a good ability for adsorption of significant content of the drug and very slow release.

Quick removal of metronidazole from aqueous solutions using metal–organic frameworks

“…The band emerging at 768 cm −1 is attributable to the Fe–OH group, representing an abundance of surface active sites. 45 The FTIR results confirm well the formation of HKUST-1 and NH 2 -MIL-101-Fe 50,51 (Fig. 1).…”

“…NH 2 -MIL-101-Fe was synthesized by adapting a reported solvothermal method. 51 Briefly, iron( iii ) chloride hexahydrate (2.663 mmol) was dissolved in DMF (8.0 mL), followed by adding 2-aminoterephthalic acid (1.423 mmol) under stirring at 25 °C. The solution was placed into a 100 mL Teflon-lined stainless steel autoclave and kept at 110 °C for 24 h. After gradual cooling to 25 °C for 3 h, the autoclave was opened and the resultant brown powder was centrifuged and rinsed with DMF and methanol several times, followed by vacuum-drying at 60 °C overnight to produce NH 2 -MIL-101-Fe (yield: 69%, based on 2-aminoterephthalic acid).…”

Current status and prospects of MIL-based MOF materials for biomedicine applications

“…An evaluation of the slow-release performance of ibuprofen over six days using these different functional MIL-101(Fe) materials showed good drug adsorption capacity and slow-release properties. 24 It is evident that MIL-100(Fe) and MIL-101(Fe) have significant advantages in the delivery of NSAIDs. First, the large specific surface area of these materials allows for high drug loading, reducing the need for frequent dosing.…”