Diosgenin-induced autophagy and apoptosis in a human prostate cancer cell line

Abstract

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Induction of G2/M Phase Arrest by Diosgenin via Activation of Chk1 Kinase and Cdc25C Regulatory Pathways to Promote Apoptosis in Human Breast Cancer Cells

“…Diosgenin exerts its tumor suppressive function to induce apoptosis by down-regulating MALAT1/STAT3 signaling in gefitinib-resistant non-small cell lung cancer [30]. In addition, diosgenin activates tumor cell autophagy and apoptosis by inhibiting the phosphorylation of phosphoinositide 3-kinase, Akt, and the mammalian target of rapamycin, thereby decreasing signaling through this pathway [31]. Furthermore, diosgenin can improve intestinal microbiota, which may increase immune functions to enhance the therapeutic efficacy of the checkpoint protein, PD-1, when treating melanoma [32].…”

Exploring the impact of a naturally occurring sapogenin diosgenin on underlying mechanisms of Ca2+ movement and cytotoxicity in human prostate cancer cells

“…Thus, the concentration responses of diosgenin‐induced cytotoxicity appear to vary among prostate cancer cell types. Previous studies have demonstrated that diosgenin between 30 and 240 μM caused cyotoxicity for 48 hours in DU145 human prostate cancer cells . The DU145 cell line was derived from a central nervous system metastasis, of primary prostate adenocarcinoma origin, removed during a parieto‐occipital craniotomy .…”

Propagule Powder of Japanese Yam (Dioscorea Japonica) Reduces High‐Fat Diet‐Induced Metabolic Stress in Mice through the Regulation of Hepatic Gene Expression

“…Though it is supposed that the main ingredients contained in Japanese yams are polysaccharides, proteins, and amino acids, which are responsible for its medicinal action, [ 3–6 ] there are not enough data in vivo. Diosgenin, which is a physiologically active substance found in yam species and extracts of yam, was investigated to assess its functionality, [ 7,8 ] but few studies have been performed that use whole Japanese yam in vivo. [ 9,10 ] The results of cultured cells indicated that diosgenin had the ability to cure hepatic fibrosis and inhibit the proliferation of cancer cells.…”

“…[ 9,10 ] The results of cultured cells indicated that diosgenin had the ability to cure hepatic fibrosis and inhibit the proliferation of cancer cells. [ 7,8 ] Chronic administration of Sanyaku inhibited an increase in body weight, but a single administration of diosgenin did not have an effect on body weight. [ 9 ] Kusano et al.…”