Diosgenin Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose

Abstract

This study attempted to access the neuroprotective effect of diosgenin on the senescent mice induced by d-galactose (D-gal). The mice in the experiments were orally administered with diosgenin (1, 5, 25 and 125 mg/kg), for four weeks from the sixth week. The learning and memory abilities of the mice in Morris water maze test and the mechanism involved in the neuroprotective effect of diosgenin on the mice brain tissue were investigated. Diosgenin (5, 25 and 125 mg/kg, p.o.) showed significantly improved learning and memory abilities in Morris water maze test compared to D-gal treated mice (200 mg/kg, ten weeks). Diosgenin also increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and decreased the malondialdehyde (MDA) level in the brain of D-gal treated mice. These results indicated that diosgenin has the potential to be a useful treatment for cognitive impairment. In addition, the memory enhancing effect of diosgenin may be partly mediated via enhancing endogenous antioxidant enzymatic activities.

Diosgenin, a Steroid Saponin Constituent of Yams and Fenugreek: Emerging Evidence for Applications in Medicine

“…Furthermore, a combination of diosgenin and interferon-α exerted an additive effect on the resultant anti-HCV activity (Wang et al, 2011). The neuroprotective effect of diosgenin against d-galactose-induced senescence in mice by improving cognitive abilities as assessed through the Morris water maze test and mediated by enhancing endogenous antioxidant enzyme activities (Chiu et al, 2011). Diosgenin induced apoptosis in non-cancerous human rheumatoid arthritis synoviocytes (RAS) through the overexpression of COX-2 protein and concomitant increase in the level of prostaglandin (PG)-E 2 (Liagre et al, 2004(Liagre et al, , 2007.…”

Фитосапонины Диоскореи: Перспективы Использования У Женщин

“…Ïåðî-ðàëüíîå ââåäåíèå äèîñãåíèíà (5, 25 è 125 ìã/êã â òå÷å-íèå 4 íåäåëü) äîñòîâåðíî óëó÷øàåò ñïîñîáíîñòü aeè-âîòíûõ ê ïðîñòðàíñòâåííîìó îáó÷åíèþ â âîäíîì òåñ-òå Ìîððèñà [28,29]. Äèîñãåíèí â ýòèõ aeå äîçàõ òàêaeå ïîâûøàåò àêòèâíîñòü ñóïåðîêñèääèñìóòàçû è ãëóòà-òèîíïåðîêñèäàçû, è ñíèaeàåò óðîâåíü ìàëîíîâîãî äè-àëüäåãèäà â òêàíè ãîëîâíîãî ìîçãà, ÷òî óêàçûâàåò íà àíòèîêñèäàíòíûå ñâîéñòâà äàííîãî âåùåñòâà [27]. Ïî-ëàãàþò, ÷òî àíòèàìíåñòè÷åñêèé ýôôåêò äèîñãåíèíà îáóñëîâëåí ïîâûøåíèåì àêòèâíîñòè ôåðìåíòîâ àíòè-îêñèäàíòíîé çàùèòû.…”

“…Ïî-ëàãàþò, ÷òî àíòèàìíåñòè÷åñêèé ýôôåêò äèîñãåíèíà îáóñëîâëåí ïîâûøåíèåì àêòèâíîñòè ôåðìåíòîâ àíòè-îêñèäàíòíîé çàùèòû. Ýïèäåìèîëîãè÷åñêèå äàííûå ðåòðîñïåêòèâíûõ è ïëàöåáî-êîíòðîëèðóåìûõ èññëåäî-âàíèé ñâèäåòåëüñòâóþò î òîì, ÷òî âêëþ÷åíèå â ðàöèîí ïèòàíèÿ ïîñòìåíîïàóçàëüíûõ aeåíùèí áèîëîãè÷åñêè àêòèâíûõ äîáàâîê äèêîãî ÿìñà (ýêñòðàêò êîðíåé äèî-ñêîðåè) ñóùåñòâåííî ñíèaeàåò ïîÿâëåíèå è ðàçâèòèå ðàçëè÷íûõ íåéðîäåãåíåðàòèâíûõ çàáîëåâàíèé, â òîì ÷èñëå áîëåçíè Àëüöãåéìåðà [26,27].…”

A review on pharmacological and analytical aspects of diosgenin: a concise report

“…It showed increased activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) and decreased malondialdehyde (MDA) level in the brain of d-galactose treated mice. 36 Effect of diosgenin for a period of 35 days on lysosomal hydrolases, membrane-bound enzymes, and electrolytes during isoproterenol induced myocardial necrosis in rats was investigated. Diosgenin pretreated groups showed significant decrease in CK-MB, lipid peroxidation, and lysosomal hydrolases activity.…”