Dioscoreophyllum cumminsii (Stapf) Diels leaves halt high-fructose induced metabolic syndrome: Hyperglycemia, insulin resistance, inflammation and oxidative stress

Ajiboye, Taofeek O.; Aliyu, Habibu; Tanimu, M.A.; Muhammad, Rateb; Ibitoye, O.B.

doi:10.1016/j.jep.2016.08.024

Cited by 26 publications

(27 citation statements)

References 41 publications

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“…Evidence indicates that increased LDL-C and decreased HDL-C levels are associated with a higher risk of CVD (Ng et al, 2014). These changes in lipids, as observed in this study and previously established in rats, could predispose to the risk of atherosclerosis and cardiovascular disease development (Ajiboye et al, 2016). Moreover, for decades, lipid profile was of profound importance for determining the cardiovascular risk.…”

Section: Discussionsupporting

confidence: 76%

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Famurewa¹,

Nwankwo

Folawiyo

et al. 2017

Acta Sci Pol Technol Aliment

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Background. The literature reports that the health benefits of vegetable oil can be deteriorated by repeated heating, which leads to lipid oxidation and the formation of free radicals. Virgin coconut oil (VCO) is emerging as a functional food oil and its health benefits are attributed to its potent polyphenolic compounds. We investigated the beneficial effect of VCO supplementation on lipid profile, liver and kidney markers in rats fed repeatedly heated palm kernel oil (HPO). Material and methods. Rats were divided into four groups (n = 5). The control group rats were fed with a normal diet; group 2 rats were fed a 10% VCO supplemented diet; group 3 administered 10 ml HPO/kg b.w. orally; group 4 were fed 10% VCO + 10 ml HPO/kg for 28 days. Subsequently, serum markers of liver damage (ALT, AST, ALP and albumin), kidney damage (urea, creatinine and uric acid), lipid profile and lipid ratios as cardiovascular risk indices were evaluated. Results. HPO induced a significant increase in serum markers of liver and kidney damage as well as concomitant lipid abnormalities and a marked reduction in serum HDL-C. The lipid ratios evaluated for atherogenic and coronary risk indices in rats administered HPO only were remarkably higher than control. It was observed that VCO supplementation attenuated the biochemical alterations, including the indices of cardiovascular risks. Conclusion. VCO supplementation demonstrates beneficial health effects against HPO-induced biochemical alterations in rats. VCO may serve to modulate the adverse effects associated with consumption of repeatedly heated palm kernel oil.

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Section: Discussionsupporting

confidence: 76%

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Famurewa¹,

Nwankwo

Folawiyo

et al. 2017

Acta Sci Pol Technol Aliment

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“…Indeed, studies have substantiated the existence of oxidative stress resulting from overwhelmed antioxidant defense in diabetic models (Oloyede et al, , ). SOD, CAT, and GSH contents of rat liver reduced significantly when compared to rats from the control group (Figure a–c), suggesting oxidative onslaught on cellular macromolecules (Ajiboye et al, ). Contrasting increase in MDA in the liver of diabetic rats further confirm oxidative attack on cellular macromolecules including lipids (Figure d).…”

Section: Resultsmentioning

confidence: 91%

Antidiabetic activity‐guided isolation of gallic and protocatechuic acids fromHibiscus sabdariffacalyxes

et al. 2019

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We isolated and identified gallic and protocatechuic acids as the antidiabetic principles in Hibiscus sabdariffa using solvent extraction, column chromatographic fractionation, and nuclear magnetic resonance (NMR) spectroscopy. Ethylacetate fraction of the aqueous extract of H. sabdariffa inhibited α‐amylase and α‐glucosidase with IC50 of 411.73 and 433.93 μg/ml, respectively. Furthermore, fractions I and II obtained from column chromatography inhibited α‐amylase with IC50 of 27.03 and 20.12 μg/ml, and α‐glucosidase with IC50 of 24.30 and 22.29 μg/ml, respectively. In addition, the principles reduced the serum glucose and lipid peroxide levels of diabetic rats and with an improvement in the rat lipid profiles and antioxidant defenses. Fractions I and II were identified as protocatechuic acid and gallic acid, respectively, using 1H and 13C NMR. Protein–ligand docking showed that these compounds form multiple favorable interactions with the active‐site residues of the two glycosidases. Overall, protocatechuic and gallic acids emerge as natural antidiabetic agents. Practical applications Hibiscus sabdariffa (Zoborodo) is a refreshment drink for ceremonial gatherings in Nigeria. Also, its pharmacological use includes diabetes, hypertension, hyperlipidemia, metabolic syndrome, and hepatoprotection. The consumption of this food drink could improve diabetes, hypertension, dyslipidemia, metabolic syndrome, and liver disease. Furthermore, the inhibition of α‐amylase and α‐glucosidase could prevent diabetic complications associated with postprandial glucose. Developing the extract of H. sabdariffa calyx as food supplement could be used in managing diabetes and its associated complications such as dyslipidemia, hypertension, and metabolic syndrome.

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“…Cardiac index (CI), atherogenic index and coronary artery index were estimated as described by Kang, Lee, and Lee et al (); Kayamori and Igarashi () and Ajiboye, Aliyu, Tanimu, Muhammad, and Ibitoye (), respectively.…”

Section: Methodsmentioning

confidence: 99%

“…Lipid profileSerum total cholesterol (TC), triglyceride (TAG) and high-density lipoprotein cholesterol (HDLc) were determined as described in commercial kits (Randox Laboratories Ltd., Antrim, UK). Low-density lipoprotein cholesterol (LDLc) and very low-density lipoprotein cholesterol (VLDLc) were calculated using the expression:Cardiac index (CI), atherogenic index and coronary artery index were estimated as described byKang, Lee, and Lee et al (2004);Kayamori and Igarashi (1994) andAjiboye, Aliyu, Tanimu, Muhammad, and Ibitoye (2016), respectively.…”

mentioning

confidence: 99%

Bioactivity-guided isolation of antidiabetic principles from the methanolic leaf extract ofBryophyllum pinnatum

et al. 2018

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The antidiabetic principles from methanolic leaf extract of Bryophyllum pinnatum were isolated. The leaf extract was fractionated on silica gel using column chromatography and identified using nuclear magnetic resonance (NMR) spectrometry. The ethylacetate fraction of the partitioned methanolic extract of B. pinnatum lowered blood glucose of alloxan‐induced diabetic rats and inhibited α‐amylase and α‐glucosidase with IC50 137.89 and 110.15 µg/mL, respectively. In addition to lowering blood glucose, fractions A and B inhibited α‐amylase with IC50 57.43 and 43.84 µg/mL and α‐glucosidase with IC50 11.15 and 25.79 µg/mL, respectively. 1H and 13C NMR showed that fractions A and B are quercetin and kaempeferol, respectively. Molecular docking revealed that kaempferol and quercetin interacted with amino acid residues that bind/hydrolyze substrate molecules These compounds reversed altered lipid profile and oxidative stress biomarkers. Our findings showed that kaempferol and quercetin are responsible for the antidiabetic activity of B. pinnatum. Practical application Bryophyllum pinnatum is an edible vegetable plant in some parts of Nigeria, and its consumption could improve diabetic condition and lower postprandial glucose. Furthermore, extract of the leaves could be developed into food supplements for managing diabetes and its associated complications including dyslipidaemia and oxidative stress.

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Dioscoreophyllum cumminsii (Stapf) Diels leaves halt high-fructose induced metabolic syndrome: Hyperglycemia, insulin resistance, inflammation and oxidative stress

Cited by 26 publications

References 41 publications

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Repeatedly heated palm kernel oil induces hyperlipidemia, atherogenic indices and hepatorenal toxicity in rats: Beneficial role of virgin coconut oil supplementation

Antidiabetic activity‐guided isolation of gallic and protocatechuic acids fromHibiscus sabdariffacalyxes

Bioactivity-guided isolation of antidiabetic principles from the methanolic leaf extract ofBryophyllum pinnatum

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