Diosbulbin B: An important component responsible for hepatotoxicity and protein covalent binding induced by Dioscorea bulbifera L.

Tan, Rong; Hu, Zixia; Zhou, Mengyue; Liu, Ying; Wang, Yan; Zou, Ying; Li, Kunna; Zhang, Shiyu; Pan, Jie; Peng, Ying; Li, Weiwei; Zheng, Jiang

doi:10.1016/j.phymed.2022.154174

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…The resulting product reacts with a primary amine to form the corresponding Schiff's base, followed by an intramolecular cyclization and dehydration. [39,40] GSH contains two nucleophilic functional groups of the sulfhydryl (the cysteine residue) and amino (the glycine residue) groups, which reacts with cis-enedial metabolite from DIOB to form intramolecular GSH pyrrole conjugates. In this study, GSH was used as the trapping agent in liver microsomal incubations, and the intramolecular GSH pyrrole conjugates were detected by LC-MS/MS according to the previous reports.…”

Section: Discussionmentioning

confidence: 99%

Glycyrrhizin protects against diosbulbin B‐induced hepatotoxicity by inhibiting the metabolic activation of diosbulbin B

Yang,

Liu,

Chang

et al. 2023

J Biochem & Molecular Tox

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Diosbulbin B (DIOB), isolated from herbal medicine Dioscorea bulbifera L. (DB), could induce severe liver injury, and its toxicology was closely associated with CYP3A4‐mediated metabolic oxidation of furan moiety to the corresponding cis‐enedial reactive metabolite. Glycyrrhizin (GL), the major bioactive ingredient in licorice, can inhibit the activity of CYP3A4. Thus, GL may ameliorate hepatotoxicity of DIOB when GL and DIOB are co‐administrated. The study aimed to investigate the protective effect of GL on DIOB‐induced hepatotoxicity and the underlying mechanism. Biochemical and histopathological analysis demonstrated that GL alleviated DIOB‐induced hepatotoxicity in a dose‐dependent manner. In vitro study with mouse liver microsomes (MLMs) demonstrated that GL reduced the formation of metabolic activation‐derived pyrrole‐glutathione (GSH) conjugates from DIOB. Toxicokinetic studies showed that the pretreatment with GL caused the increase of AUCs and Cmax of DIOB in blood of mice, resulting in accelerating the accumulation of DIOB in the circulation. In addition, the pretreatment with GL alleviated DIOB‐induced hepatic GSH depletion. In summary, GL ameliorated DIOB‐induced hepatotoxicity, possibly related to the inhibition of the metabolic activation of DIOB. Thus, development of a standardized combination of DIOB with GL may protect patients from DIOB‐induced liver injury.

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Section: Discussionmentioning

confidence: 99%

Glycyrrhizin protects against diosbulbin B‐induced hepatotoxicity by inhibiting the metabolic activation of diosbulbin B

Yang,

Liu,

Chang

et al. 2023

J Biochem & Molecular Tox

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“…Yang and colleagues reported that glycyrrhizin was hepatoprotective in a mouse model when administered with diosbulbin B (DIOB), the purported component of Dioscorea bulbifera L. responsible for liver injury [96]. This herbal agent is used for the treatment of thyroid disorders in China and has been associated with severe liver injury, which has limited its use [97]. Yang et al postulated that glycyrrhizin protects against the hepatotoxicity of this compound by inhibiting CYP3A4 and subsequently reducing the formation of pyrrole-glutathione conjugates by inhibiting the metabolic activation of DIOB.…”

Section: Corticosteroids With Glycyrrhizinmentioning

confidence: 99%

Herbal- and Dietary-Supplement-Induced Liver Injury: A Review of the Recent Literature

Patel-Rodrigues,

Cundra,

Alhaqqan

et al. 2024

Livers

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Herbal-induced liver injury (HILI) continues to increase in prevalence each year due to the ongoing popularity of herbal supplements and complementary and alternative medicines. A detailed literature review of case reports and clinical studies published from March 2021 to March 2023 was performed. We discuss the epidemiology and diagnosis of HILI as well as the current and proposed laws and regulations. The 2021 ACG guidelines and 2022 AASLD practice guidelines for the diagnosis and management of drug and herbal-induced liver injury are discussed. We describe updates to previously reported etiologies of HILI such as ayurveda, ashwagandha, turmeric, kratom, green tea extract, and garcinia cambogia. Newly described supplements resulting in HILI, such as tinospora cordifolia, horse chestnut, alkaline water, and more, are described. We discuss newly and previously identified hepatoprotective herbal supplements as they have been reported in the study of animal models and human liver cells. This review suggests the need for ongoing research on the causes and mechanisms of HILI to ensure its proper diagnosis, prevention, and treatment in the future. The goal of this review is to provide novice and expert readers with knowledge regarding the possible etiologies of HILI and a general overview.

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“…Studies on the medicinal properties of the species highlight, however, its toxicity, especially its hepatotoxicity. Most articles that address the medicinal properties of D. bulbifera propose technologies to isolate chemical compounds and inhibit the toxic effects of the plant (Guan, Zhu, Xiao, et al, 2017;Tapondjou et al, 2013;Shi, Zhang, Zhao, et al 2018;Tan et al, 2022;Qu et al, 2017;Trivedi et al, 2021;Sun et al, 2021;Ma el al, 2014;Ma et al, 2012;Lin et al, 2014;Yang et al, 2014;Li et al, 2016;Ma et al, 2018).…”

Section: Medicinal and Functional Properties Of D Bulbiferamentioning

confidence: 99%

AGROBIODIVERSITY IN AGRARIAN REFORM TERRITORIES: EXPERIENCES WITH GIZZARD YAM (Dioscorea bulbifera)

Melo,

Evangelista,

Tavares

et al. 2024

JASR

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This work proposes a look at Dioscorea bulbifera from historicalcultural and agronomic perspectives. The article reflects on the centers of origin and geographic distribution of the species, as well as its medicinal and functional properties, according to world literature. It then presents a report and analysis of experiences with gizzard yam in Agrarian Reform territories in the Federal District, Brazil. To this end, a literary search was carried out on Dioscorea bulbifera, through which the most recurrent themes in scientific approaches to the species were categorized and an analysis of studies on the species was prepared from the locus of knowledge production. Based on productive characteristics, four agronomic experiments were also evaluated to focus on agrotechnical recommendations aimed at the traditional planting of Dioscorea bulbifera, conducted on live posts. Finally, future perspectives are discussed in order to think about different ways of managing the plant and the valorization of gizzard yam in family farming in agrarian reform territories.

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Diosbulbin B: An important component responsible for hepatotoxicity and protein covalent binding induced by Dioscorea bulbifera L.

Cited by 10 publications

References 25 publications

Glycyrrhizin protects against diosbulbin B‐induced hepatotoxicity by inhibiting the metabolic activation of diosbulbin B

Glycyrrhizin protects against diosbulbin B‐induced hepatotoxicity by inhibiting the metabolic activation of diosbulbin B

Herbal- and Dietary-Supplement-Induced Liver Injury: A Review of the Recent Literature

AGROBIODIVERSITY IN AGRARIAN REFORM TERRITORIES: EXPERIENCES WITH GIZZARD YAM (Dioscorea bulbifera)

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