Diol responsive viscosity increase in a cetyltrimethylammonium bromide/sodium salicylate/3-fluorophenylboronic acid micelle system

Abstract

We report a novel smart micellar system utilising a phenylboronic acid (PBA) derivative whose viscosity increases on adding diol compounds such as sugar or sugar alcohol.

Phenylboronate-salicylate ester cross-linked self-healing hydrogel composed of modified hyaluronan at physiological pH

“…For quantitatively evaluating the two crucial properties of selfhealing hydrogels, namely, gelation and viscosity, dynamic viscoelasticity measurement is a widely used method. 12,13,[27][28][29][30]35 The dynamic viscoelastic properties of BA-HA/Sal-HA were investigated. The storage modulus (G 0 ) and loss modulus (G 00 ) were obtained from the dynamic viscoelasticity measurements, which showed the solid and liquid properties, respectively.…”

“…The G 0 and G 00 values of boronate-ester-cross-linked hydrogels are strongly frequency (o) dependent. 12,13,[27][28][29][30]35 The frequency dependence of the BA-HA/Sal-HA system was investigated at a fixed strain of 10% (Fig. 7a).…”

“…The boronate-ester-cross-linked hydrogels possess the sugarresponsive ability to transform into a sol; thus, their dynamic viscoelasticities were evaluated for application to sugarresponsive drug release. 10,27,30,36,37 The sugar concentration dependency of the G 0 and G 00 values at 10 rad s À1 was investigated for the BA-HA/Sal-HA system (Fig. 7e).…”

“…26 PBA-moieties modified HAs have also been reported, and a hydrogel is produced by self-crosslinking a PBA moiety with the diol of HA. [27][28][29][30] However, PBA-moieties modified HAs also have some limitations. Although standard PBA derivatives can be modified to HA using a single step synthesis method, a hydrogel is formed only under the basic condition (pH 9.2-10.5).…”

“…Although standard PBA derivatives can be modified to HA using a single step synthesis method, a hydrogel is formed only under the basic condition (pH 9.2-10.5). [27][28][29] Some benzoxaborole derivatives-modified HA can form hydrogels under physiological pH conditions. 30 However, multi-step syntheses are required to synthesize benzoxaborole derivatives.…”