Diode laser-induced thermal damage evaluation on the retina with a liposome dye system

Desmettre, Thomas; Bégu, Sylvie; Devoisselle, Jean Marie; Mordon, Serge

doi:10.1002/(sici)1096-9101(1999)24:1<61::aid-lsm10>3.0.co;2-g

Cited by 24 publications

(9 citation statements)

References 27 publications

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“…In principle, this can be accomplished with PT sensors with a known light absorption and size like organic materials, metal spheres, etc. In this study, we have applied liposomes which recently were successfully been used in fluorescent diagnostics [38][39][40] and for the monitoring of the laser-induced heating [41][42][43]. Due to small size (30-2,000 nm), cell-like composition (it can be introduced into the living cells), dominant of non-radiative relaxation of absorbed energy and reasonable photostability, liposomes are convenient as test objects for PTI.…”

Section: Sample Preparationmentioning

confidence: 99%

Photothermal time‐resolved imaging of living cells

Lapotko¹,

Romanovskaya²,

Shnip³

et al. 2002

Lasers Surg Med

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Section: Sample Preparationmentioning

confidence: 99%

Photothermal time‐resolved imaging of living cells

Lapotko¹,

Romanovskaya²,

Shnip³

et al. 2002

Lasers Surg Med

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“…Such binding results in rapid clearance of ICG from blood (with plasma half-life in the order of 2-4 minutes). 26 We 7-11 and others [27][28][29][30] are pursuing encapsulation of ICG as a potential approach to increase its circulation time with the intention of broadening the medical applications of this clinically proven optical material.…”

Section: Introductionmentioning

confidence: 99%

Effects of nanoencapsulation and PEGylation on biodistribution of indocyanine green in healthy mice: quantitative fluorescence imaging and analysis of organs

Bahmani¹,

Lytle²,

Walker³

et al. 2013

IJN

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Near-infrared nanoconstructs present a potentially effective platform for site-specific and deep tissue optical imaging and phototherapy. We have engineered a polymeric nanocapsule composed of polyallylamine hydrochloride (PAH) chains cross-linked with sodium phosphate and doped with indocyanine green (ICG) toward such endeavors. The ICG-doped nanocapsules were coated covalently with polyethylene glycol (5000 daltons) through reductive amination. We administrated the constructs by tail vein injection to healthy mice. To characterize the biodistribution of the constructs, we performed in vivo quantitative fluorescence imaging and subsequently analyzed the various extracted organs. Our results suggest that encapsulation of ICG in these PEGylated constructs is an effective approach to prolong the circulation time of ICG and delay its hepatic accumulation. Increased bioavailability of ICG, due to encapsulation, offers the potential of extending the clinical applications of ICG, which are currently limited due to rapid elimination of ICG from the vasculature. Our results also indicate that PAH and ICG-doped nanocapsules (ICG-NCs) are not cytotoxic at the levels used in this study.

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“…Though, it should be kept in mind that the retina can be damaged by light (i.e. laser and sungazing) at 42 1C not through thermal but through mechanical and photochemical processes (Desmettre et al, 1999;Glickman, 2002). Therefore, laser is unlikely suitable for creating the thermal effect to remove the vitreous in practice in the clinic; a heating system similar to the present one may be suitable, but its safety and practicality require further investigation.…”

Section: Discussionmentioning

confidence: 91%