Dioclein, a flavanone from the roots of Dioclea grandiflora

Mechanisms Involved in the Vasodilator Effect of the Flavanol Floranol in Rat Small Mesenteric Arteries

“…ex Benth. In previous studies we described the vasodilator and anti-hypertensive [6], [7], [8] effect of dioclein (2) a flavanone isolated from the roots of the same plant [9]. In the present work, we describe for the fist time the vasodilator effect of floranol in rat small mesenteric arteries and the underling mechanism of this effect.…”

Toxicidade Aguda em Ratos Wistar Tratados com o Extrato Etanólico de Dioclea grandiflora Mart. Ex Benth (Fabaceae) (EEDg)

“…De acordo com a tradição popular, a casca das sementes desta planta e das raízes têm sido amplamente utilizados para tratar doenças da próstata e pedras nos rins 7 . Estudos fitoquímicos mostrou a presença de várias substâncias na Dioclea grandiflora, tais como o paraibanol, agrandol e diosalol (8), dioclein, dioflorin, diidroflavonol, dioclenol [9][10] , isolado a partir do clorofórmio (CHCI3) porção solúvel do extrato de casca da raiz desta planta. Investigações anteriores evidenciaram uma atividade significativa no SNC do extrato etanólico obtido a partir da casca da raiz seca 11 , e do extrato hidroalcoólico a partir das sementes de Dioclea grandiflora 12 .…”

Total assignments of 1H and 13C NMR spectra of a new prenylated flavanone from Dioclea grandiflora

“…An infusion of the roots of this plant is used for the treatment of kidney stones and prostate gland disorders. 1 In a previous study, dioclein (2) a new flavanone isolated as the major constituent of D. grandiflora 2 was described as being a vasodilator and anti-hypertensive. 3 -6 Other minor prenylated flavanones were also isolated from this plant.…”