Dinucleotide repeat polymorphism at the human biglycan (BGN) locus

Just, Walter; Rau, W.; Müller, Ralf; Geerkens, Claudia; Vogel, Walther

doi:10.1093/hmg/3.12.2268

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Polymorphism Among Replaced Strs and Str-couples1

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Cited by 3 publications

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“…5A). These polymorphic sequences were embedded in flanking sequences that were 100% conserved among the five mRNAs (Just et al, 1994;Altschul et al, 1997). Similarly, Igsf-9 mRNAs were polymorphic in both STRs of their STRcouple in M. musculus (Fig.…”

Section: Polymorphism Among Replaced Strs and Str-couplesmentioning

confidence: 99%

Simple repeat replacements support similar functions of distinct repeats in inter-species mRNA homologs

Riley

Krieger

2004

Gene

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Section: Polymorphism Among Replaced Strs and Str-couplesmentioning

confidence: 99%

Simple repeat replacements support similar functions of distinct repeats in inter-species mRNA homologs

Riley

Krieger

2004

Gene

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Haemopoietic biglycan produced by brain cells stimulates growth of microglial cells

Kikuchi

Tomoyasu

Kido

et al. 2000

Journal of Neuroimmunology

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Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia

Fox

Lamperti

Ekşioğlu

et al. 1998

Neuron

803

568

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Long-range, directed migration is particularly dramatic in the cerebral cortex, where postmitotic neurons generated deep in the brain migrate to form layers with distinct form and function. In the X-linked dominant human disorder periventricular heterotopia (PH), many neurons fail to migrate and persist as nodules lining the ventricular surface. Females with PH present with epilepsy and other signs, including patent ductus arteriosus and coagulopathy, while hemizygous males die embryonically. We have identified the PH gene as filamin 1 (FLN1), which encodes an actin-cross-linking phosphoprotein that transduces ligand-receptor binding into actin reorganization, and which is required for locomotion of many cell types. FLN1 shows previously unrecognized, high-level expression in the developing cortex, is required for neuronal migration to the cortex, and is essential for embryogenesis.

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Dinucleotide repeat polymorphism at the human biglycan (BGN) locus

Cited by 3 publications

References 0 publications

Simple repeat replacements support similar functions of distinct repeats in inter-species mRNA homologs

Simple repeat replacements support similar functions of distinct repeats in inter-species mRNA homologs

Haemopoietic biglycan produced by brain cells stimulates growth of microglial cells

Mutations in filamin 1 Prevent Migration of Cerebral Cortical Neurons in Human Periventricular Heterotopia

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