Dinuclear zinc(ii) complexes containing (benzimidazol-2-yl)benzene that overcome drug resistance in hepatocellular carcinoma cells through induction of mitochondria fragmentation

Abstract

Herein we demonstrated that dinuclear zinc complexes could overcome drug resistance in R-HepG2 drug resistance hepatocellular carcinoma cells through induction of mitochondria-mediated apoptosis or by triggering mitochondria fragmentation, depletion of the membrane potential and intracellular ATP levels.

Mitochondria‐Targeting Photocytotoxic Ferrocenyl Conjugates of N‐Alkylpyridinium Salts

“…The loss of mitochondrial membrane potential is an indication that apoptosis proceeds by a mitochondrial pathway 28. Damage to mitochondria leads to its depolarization with a drop in Δ Ψ m 48,49. JC‐1 is a lipophilic cationic dye that spontaneously forms aggregates in healthy cells with high mitochondrial potential (Δ Ψ m ); this results in intense red fluorescence (ca.…”

Structure of the mercury(II) mixed-halide (Br/Cl) complex of 2,2′-(5-tert-butyl-1,3-phenylene)bis(1-pentyl-1H-benzo[d]imidazole)

“…A trimeric complex has been obtained through the self assembly of cyclometalated trinuclear palladium(II) complexes (Rü ttimann et al, 1993). Dinuclear zinc complexes containing (benzimidazol-2-yl)benzene based ligands have shown anticancer activities (Xie et al, 2014).…”

Synthesis, structure, photoluminescence and antitumour activity of zinc complex based on 2-(2-(1H-benzo-[d]imidazol-2-yl)benzyl)-1H-benzo-[d]imidazole

“…For instance, Terenzi et al found that zinc complexes based on 2,5-diphenyl [1,3,4]oxadiazole derivative could bind to DNA and inhibit the proliferation of human carcinoma cells. In recent, zinc complexes based on benzimidazole compound draw our attention for their biological activities [7][8]. Esophageal cancer has the highest incidence and mortality rates in China.…”