Dinuclear [{(p-cym)RuCl}2(μ-phpy)](PF6)2 and heterodinuclear [(ppy)2Ir(μ-phpy)Ru(p-cym)Cl](PF6)2 complexes: synthesis, structure and anticancer activity

Tripathy, Suman Kumar; De, Umasankar; Dehury, Niranjan; Pal, Satyanarayan; Kim, Hyung Sik; Patra, Srikanta

doi:10.1039/c4dt01033g

Cited by 44 publications

(56 citation statements)

References 43 publications

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“…Methyl-and fluoro-substituted phenylpyridine-iridium complexes C1 and C2 with L were synthesized and characterized by minor modifications to our previouslyr eported method. [31,32] We next turned our attention to their UV/Vis spectroscopic and fluorescencep roperties in both water and dimethyl sulfoxide (DMSO). Ag ood overlap in excitation and absorption spectra for both complexes confirms their spectroscopic purity (Supporting Information Figure S1).…”

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confidence: 99%

Iridium Complexes as a Roadblock for DNA Polymerase during Amplification

et al. 2016

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Iridium-based metal complexes containing polypyridyl-pyrazine ligands show properties of DNA intercalation. They serve as roadblocks to DNA polymerase activity, thereby inhibiting the polymerization process. Upon the addition of increasing concentrations of these iridium complexes, a rapid polymerase chain reaction (PCR)-based assay reveals the selective inhibition of the DNA polymerization process. This label-free approach to study the inhibition of fundamental cellular processes via physical roadblock can offer an alternative route toward cancer therapy.

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confidence: 99%

Iridium Complexes as a Roadblock for DNA Polymerase during Amplification

et al. 2016

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“…[38][39][40] While the longer wavelength absorption shoulders above 400 nm might be assigned as an admixture of spin-allowed metal-to-ligand charge-transfer ( 1 MLCT : d π → π * phen ) and ligand-to-ligand charge transfer ( 1 LLCT : π ppy → π * phen ) processes. 3,[41][42][43][44][45] The very low-intensity band observed in the range 400-500 nm (Figure 2(a)) might be assigned as spin-forbidden 3 MLCT and 3 LLCT transitions. This observation is not consistent with the similarly reported complexes.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

“…This observation is not consistent with the similarly reported complexes. 3,[42][43][44][45][46][47] No noticeable changes in band position were observed for the complexes indicating that the substituents at the imidazo end have a negligible or no effect on the metal centres.…”

Section: Synthesis and Characterizationmentioning

confidence: 99%

“…This is primarily due to their inertness leading to low toxicity and lesser side effects, bioavailability and cancer cell selectivity as compared to wellknown cisplatin. [1][2][3] In addition, iridium complexes are known to induce selective kinase inhibition property and often display non-apoptotic mode of cancer cell death which are useful for the treatment of resistant cancer. 1,[4][5][6][7][8][9] Moreover, the exciting luminescence properties of iridium complexes are often used as probes for understanding biological processes.…”

Section: Introductionmentioning

confidence: 99%

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Cyclometallated imidazo-phenanthroline iridium complexes and their anticancer activity

Garg

Dehury

et al. 2018

J Chem Sci

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Cyclometallated mononuclear iridium complexes (1-3) were synthesized using dimeric precursor [(ppy) 2 Ir III (μ-Cl)] 2 and imidazo-phenanthroline-based ligands (L 1-L 3). The complexes were characterised using various analytical techniques. The complexes exhibited spin forbidden metal-to-ligand charge transfer (MLCT) transitions at wavelengths >300 nm and high energy ligand-based transition below 300 nm. The complexes were found to be emissive and displayed emission bands at 580 nm upon excitation at 380 nm with quantum yields 0.07 with respect to standard [Ru(bpy) 3 ]Cl 2. The complexes 1-3 showed dose-dependent suppression of cell viability (IC 50 values ∼2.5 μM) towards human breast (MCF7) cancer cell line. The hydrophobicity measurements and flow cytometry analysis suggest that cellular uptake is primarily responsible for observed cytotoxicity.

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“…The cell viability of the green synthesised Au@AgClNP was assayed by standard MTT (3-(4,5-dimethylthiazol-2-yl)-2-5-diphenyl tetrazolium bromide) assay by following the procedure reported earlier. 52…”

Section: Cellular Toxicity Assaymentioning

confidence: 99%