Dinuclear gold(i) complexes with N-phosphanyl, N-heterocyclic carbene ligands: synthetic strategies, luminescence properties and anticancer activity

Abstract

A small library of dinuclear gold(I) complexes with the title ligands has been prepared, encompassing, neutral, mono- and dicationic complexes. The luminescence properties of the complexes in the solid state...

Recent development of gold(i) and gold(iii) complexes as therapeutic agents for cancer diseases

“…The results showed that complex 225 was the best complex with an IC 50 value of 0.22 AE 0.07 mM against HCT116 cells. 166 In 2021, Menia et al synthesized gold(I) complexes containing cobaltoceniumselenolate ligand and characterized their structures using 1 H/ 13 C/ 31 P/ 77 Se NMR, IR, UV-Vis, HR-MS, and single crystal XRD. Complex 226 was the most active complex with IC 50 values of 8.4 AE 0.9 mM against A549, 5.0 AE 0.2 mM against HT-29, and 3.6 AE 0.3 mM against MDA-MB-231 cells.…”

From Au11 to Au13: Tailored Synthesis of Superatomic Di-NHC/PPh3-Stabilized Molecular Gold Nanoclusters

“…Our group has a longstanding experience in the chemistry of dinuclear gold­(I) complexes with di-NHC ligands, − and we envisaged the possibility of exploiting them in an alternative way as reagents for the preparation of novel NHC-stabilized AuNCs (Scheme C). Our synthetic approach involves the use of these complexes, which are more stable and easily manipulated than free di-NHCs, for the chemical modification of preformed AuNCs.…”

Bilateral metalloheterocyclic systems based on palladacycle and piperidine-2,4-dione pharmacophores

“…1). 4,5 Extensive research in the field of cancer therapy has additionally revealed many promising derivatives of other noble metals, 6 including complexes of Au, 7–11 Ru, 12–16 Os, 12 Ir, 17–20 and Rh. 21–24…”

“…1). 4,5 Extensive research in the field of cancer therapy has additionally revealed many promising derivatives of other noble metals, 6 including complexes of Au, [7][8][9][10][11] Ru, [12][13][14][15][16] Os, 12 Ir, [17][18][19][20] and Rh. [21][22][23][24] To the mentioned complexes, palladacycles, which are a broad class of organometallic compounds with high synthetic and medical potential, can be added.…”