Dinuclear cobalt(II) complexes of Schiff-base compartmental ligands: Syntheses, crystal structure and bio-relevant catalytic activities

Theoretical and experimental investigation of anticancer activities of an acyclic and symmetrical compartmental Schiff base ligand and its Co(ii), Cu(ii) and Zn(ii) complexes

“…In addition to the expected biological properties of the Schiff base compounds, [30][31][32][33][34][35] binding the cobalt, copper and zinc atoms to this unit make these complexes a good prospect for biologically active compounds [36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] (31)(32)(33)(34)(35) for zinc, 36-40 for cobalt, 41-45 for copper). For the study of the biological activities of new ligand (H 3 L Br ) and its complexes 1-3, docking calculations were run to investigate the possibility of interaction between these compounds with nine protein targets, including: BRAF kinase, cathepsin B (CatB), DNA gyrase, histone deacetylase (HDAC7), recombinant human albumin (rHA), ribonucleotide reductases (RNR), thioredoxin reductase (TrxR), thymidylate synthase (TS), topoisomerase II (Top II).…”

Investigation of 3d-transition metal acetates in the oxidation of substituted dioxolene and phenols

“…The metals were chosen from the list of 3d-metals used so far to design mimics of CO or PHS using different ligand systems viz. copper [24,, iron [25,[55][56][57], cobalt [58][59][60][61][62][63][64][65], manganese [66][67][68][69][70][71][72][73][74][75][76][77][78][79], nickel [26,68,[80][81][82][83] and zinc [33,84]. PHS mimics cannot be found as much as CO but yet are well studied with 3d-metals viz.…”

The synthesis, characterization and catecholase activity of dinuclear cobalt(ii/iii) complexes of an O-donor rich Schiff base ligand

“…[25][26][27][28][29][30][31][32][33][34][35][36] Among the non-copper complexes produced as mimics for catechol oxidase the number of cobalt complexes studied as models for catechol oxidase is relatively low ( Table 1). [37][38][39][40][41][42] Co II/III complexes are also known to show valence tautomerism [43][44][45][46][47][48][49] in the presence of dioxolene type substrates. A number of Co III complexes reported to exhibit valence tautomerism bear a higher number of oxygen donors per metal ion [50][51][52] compared to nitrogen donors, which is the main difference in the design while attempting to mimic catechol oxidase activity using Co II/III complexes.…”