Dinitrosyl iron complexes with glutathione as NO and NO+ donors

Borodulin, R. R.; Kubrina, L. N.; Mikoyan, V. D.; Poltorakov, Аlexander P.; Shvydkiy, V. O.; Burbaev, D. Sh.; Сереженков, В. А.; Yakhontova, E. R.; Vanin, Anatoly F.

doi:10.1016/j.niox.2012.11.001

Cited by 61 publications

(46 citation statements)

References 40 publications

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“…= 2.03 (g \ = 2.04, g k = 2.014). The binuclear form (B-DNIC) is diamagnetic and represents a thiol ether of Roussin's red salt; its diamagnetic properties are provided by spin pairing (antiferromagnetic interaction) of two Fe(NO) 2 groups through sulfur bridges of B-DNIC [3,4]. Both forms of DNIC can exist in low-molecular and protein-bound states; in the latter case, thiol-containing ligands are represented by protein residues of cysteine [1].…”

Section: Introductionmentioning

confidence: 99%

Redox conversions of dinitrosyl iron complexes with natural thiol-containing ligands

et al. 2013

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Section: Introductionmentioning

confidence: 99%

Redox conversions of dinitrosyl iron complexes with natural thiol-containing ligands

et al. 2013

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“…2, right [24][25][26]. As can be seen, the unpaired electron density is predominantly localized on the iron atom, which has a d electronic configuration.…”

Section: Introductionmentioning

confidence: 95%

“…In the course of this transfer, the positive charge on the ligands diminishes, which prevents their hydrolysis and and confers stability on DNIC. If we take into account that the decomposition of DNIC and a concomitant decay of thiol-containing ligands the distribution of electron density on the {Fe(NO) 2 [25,26].…”

Section: Introductionmentioning

confidence: 99%

In-Vitro Antibacterial Activity of Processed Moringa Oleifera Seed Extract: Kill-Time Study

Idris¹,

Muyibi²,

Jamal³

et al. 2013

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Some present-day concepts of biological activities of dinitrosyl iron complexes (DNIC) with thiol-containing ligands are reviewed. These activities are determined by the ability of DNIC to act as donors of NO and nitrosonium ions (NO + ) in various body cells and tissues. DNIC are endowed with strong vasodilator activity. Due to the latter DNIC single dose injection into animal and human organisms induces long-lasting hypotension. Moreover, DNIC suppress platelet aggregation, increase red blood cell elasticity, accelerate skin wound healing, induce penis erection in animals and exert pronounced anti-apoptotic effect on cultured non-tumor cells. These regulatory effects are due to the slow release of NO and NO + from intact DNIC at both organism and in cell cultures. Fast decomposition of DNIC, e.g., in the presence of exogenous or endogenous iron-chelating agents, results in a toxic effect of DNIC on various cells and tissues and causes apoptosis of, e.g., HeLa and Jurkat human tumor cells. More recent model studies established the ability of DNIC to suppress endometriosis in rats.

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“…This occurrс in a case of disruption in the supply of oxygen to tissues required due to the natural process of biological oxidation; it is an important component of the pathogenesis of many diseases (Manukhina et al 1999Donnan et al 2008. Such disruption may occur in post-traumatic stress disorder (Campos et al 2013), characterised by memories of the original traumatic event. Interruption of cerebral blood flow decreases the oxygen supply to the brain and also leads to brain ischaemia which can result in an ischaemic stroke, followed by damage to the brain tissue and its functions (Donnan et al 2008, Doyle et al 2008, Lambertsen et al 2012.…”

Section: Introductionmentioning

confidence: 99%

“…NO typically exerts its physiological functions by binding to the iron (Fe ) of heme or by S-nitros(yl)ation of proteins but it also participates in a number of other biochemical reactions (Vanin et al 2002, Hansen and Jensen 2010, Hill et al 2010. By activating heme-containing soluble guanylate cyclase and the ADPribosyltransferase, the NO is involved in regulating the intracellular concentration of Са ions and in the regulating of the pH at the cerebral ischaemia (Evgenov et al 2006, Erusalimsky and Moncada 2007, Borodulin et al 2013). …”

Section: Introductionmentioning

confidence: 99%

Participation of NO-synthase in Control of Nitric Oxide Level in Rat Hippocampus after Modelling of Ischaemic and Haemorrhagic Insult

Гайнутдинов¹,

Pashkevich²,

Андрианов³

et al. 2017

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Electron paramagnetic resonance (EPR) was used as a method for recording the content of the nitric oxide (NO) in hippocampal tissues of intact rats and rats after modelling of ischaemic and haemorrhagic stroke. Based on direct measurements of NO by EPR spectroscopy, it was shown that, within 5 hours after the onset of symptoms of ischaemic and haemorrhagic stroke, the formation of NO in the hippocampus was reduced by a factor of 2-3 and this reduction was maintained for a period of between 24 and 72 hours. The results show that a systemic character of a decrease in the intensity of NO production during the modelling of ischaemic events in the brain reflects the effects of central dysregulation of the functions at the level of the whole organism such that it is appropriate to consider implementing the correction of the vital systems of the body in a stroke. It has indicated that non-selective NO-synthase blocker L-NAME reduced the low level of NO production by a factor of 3 by its administration within 72 hours after post-ischaemic and haemorrhagic stroke. It was discovered however that L-NAME returns the level of NO production to baseline (control) by its administration within 5 hours after ischaemia.

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Dinitrosyl iron complexes with glutathione as NO and NO+ donors

Cited by 61 publications

References 40 publications

Redox conversions of dinitrosyl iron complexes with natural thiol-containing ligands

Redox conversions of dinitrosyl iron complexes with natural thiol-containing ligands

In-Vitro Antibacterial Activity of Processed Moringa Oleifera Seed Extract: Kill-Time Study

Participation of NO-synthase in Control of Nitric Oxide Level in Rat Hippocampus after Modelling of Ischaemic and Haemorrhagic Insult

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