Dinitrosyl Iron Complexes and other Physiological Metabolites of Nitric Oxide: Multifarious Role in Plants

Шумаев, К. Б.; Kosmachevskaya, O. V.; Чумикина, Л. В.; Топунов, А. Ф.

doi:10.1177/1934578x1601100839

Cited by 3 publications

(4 citation statements)

References 52 publications

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“…Both processes were formerly reported for Hb [ 54 , 55 , 56 ]. We also suggested the possibility of DNICs to interact with Lb [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

“…The general formula of thiol-containing DNICs is [(RS − ) 2 Fe + (NO + ) 2 ]. In Hb, from mammalian erythrocytes, one of DNIC ligands is SH-group of cysteine (cysβ93) [ 55 , 56 , 57 , 65 ], while another binding site has not yet been determined. The amino acid residues involved in DNICs formation in soybean Lb are also not known, since there are no available cysteine residues in this protein.…”

Section: Resultsmentioning

confidence: 99%

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Expressed Soybean Leghemoglobin: Effect on Escherichia coli at Oxidative and Nitrosative Stress

et al. 2021

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Leghemoglobin (Lb) is an oxygen-binding plant hemoglobin of legume nodules, which participates in the symbiotic nitrogen fixation process. Another way to obtain Lb is its expression in bacteria, yeasts, or other organisms. This is promising for both obtaining Lb in the necessary quantity and scrutinizing it in model systems, e.g., its interaction with reactive oxygen (ROS) and nitrogen (RNS) species. The main goal of the work was to study how Lb expression affected the ability of Escherichia coli cells to tolerate oxidative and nitrosative stress. The bacterium E. coli with the embedded gene of soybean leghemoglobin a contains this protein in an active oxygenated state. The interaction of the expressed Lb with oxidative and nitrosative stress inducers (nitrosoglutathione, tert-butyl hydroperoxide, and benzylviologen) was studied by enzymatic methods and spectrophotometry. Lb formed NO complexes with heme-nitrosylLb or nonheme iron-dinitrosyl iron complexes (DNICs). The formation of Lb-bound DNICs was also detected by low-temperature electron paramagnetic resonance spectroscopy. Lb displayed peroxidase activity and catalyzed the reduction of organic peroxides. Despite this, E. coli-synthesized Lb were more sensitive to stress inducers. This might be due to the energy demand required by the Lb synthesis, as an alien protein consumes bacterial resources and thereby decreases adaptive potential of E. coli.

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“…Both processes were formerly reported for Hb [ 54 , 55 , 56 ]. We also suggested the possibility of DNICs to interact with Lb [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Expressed Soybean Leghemoglobin: Effect on Escherichia coli at Oxidative and Nitrosative Stress

et al. 2021

Self Cite

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“…S-nitrosation, based on the NO equivalent transfer to cysteine thiol, is the subsequent reversible redox and NO-dependent post-translational protein modification (PTM) regulating the activity of many proteins, including R and PR (pathogenesis-related) proteins working in cooperation with transcription factors [ 14 , 15 , 16 , 17 ]. Some of the essential NO activities result from its covalent binding to the ferrous heme in proteins or the formation of nitrosyl–iron complexes (DNICs) [ 18 ]. NO in direct or indirect interactions with target proteins and other NO-dependent post-stress processes can affect plant immunity.…”

Section: Introductionmentioning

confidence: 99%

Nitric Oxide Implication in Potato Immunity to Phytophthora infestans via Modifications of Histone H3/H4 Methylation Patterns on Defense Genes

Drozda

Kurpisz

Arasimowicz‐Jelonek

et al. 2022

IJMS

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Nitric oxide (NO) is an essential redox-signaling molecule operating in many physiological and pathophysiological processes. However, evidence on putative NO engagement in plant immunity by affecting defense gene expressions, including histone modifications, is poorly recognized. Exploring the effect of biphasic NO generation regulated by S-nitrosoglutathione reductase (GNSOR) activity after avr Phytophthora infestans inoculation, we showed that the phase of NO decline at 6 h post-inoculation (hpi) was correlated with the rise of defense gene expressions enriched in the TrxG-mediated H3K4me3 active mark in their promoter regions. Here, we report that arginine methyltransferase PRMT5 catalyzing histone H4R3 symmetric dimethylation (H4R3sme2) is necessary to ensure potato resistance to avr P. infestans. Both the pathogen and S-nitrosoglutathione (GSNO) altered the methylation status of H4R3sme2 by transient reduction in the repressive mark in the promoter of defense genes, R3a and HSR203J (a resistance marker), thereby elevating their transcription. In turn, the PRMT5-selective inhibitor repressed R3a expression and attenuated the hypersensitive response to the pathogen. In conclusion, we postulate that lowering the NO level (at 6 hpi) might be decisive for facilitating the pathogen-induced upregulation of stress genes via histone lysine methylation and PRMT5 controlling potato immunity to late blight.

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“…Therefore, the half-life of NO in vivo may be in the range of only a few seconds or even less (Lancaster, 1997). Thus, organisms had to evolve physiological forms of NO storage and transportation like S-nitrosoglutathione (GSNO) and dinitrosyl iron complexes (DNICs) (Mikoyan, Burgova, Borodulin, & Vanin, 2017;Shumaev, Kosmachevskaya, Chumikina, & Topunov, 2016) ( Figure 1). It has been described that especially GSNO, the condensation product of glutathione and NO, is a naturally occurring NO reservoir and also a reactive nitrogen intermediate.…”

Section: Nitric Oxide Production and Consumption In Root Cellsmentioning

confidence: 99%

Physiological significance of pedospheric nitric oxide for root growth, development and organismic interactions

Wendehenne

Philippot

et al. 2020

Plant Cell & Environment

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Nitric oxide (NO) is essential for plant growth and development, as well as interactions with abiotic and biotic environments. Its importance for multiple functions in plants means that tight regulation of NO concentrations is required. This is of particular significance in roots, where NO signalling is involved in processes, such as root growth, lateral root formation, nutrient acquisition, heavy metal homeostasis, symbiotic nitrogen fixation and root–mycorrhizal fungi interactions. The NO signal can also be produced in high levels by microbial processes in the rhizosphere, further impacting root processes. To explore these interesting interactions, in the present review, we firstly summarize current knowledge of physiological processes of NO production and consumption in roots and, thereafter, of processes involved in NO homeostasis in root cells with particular emphasis on root growth, development, nutrient acquisition, environmental stresses and organismic interactions.

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Dinitrosyl Iron Complexes and other Physiological Metabolites of Nitric Oxide: Multifarious Role in Plants

Cited by 3 publications

References 52 publications

Expressed Soybean Leghemoglobin: Effect on Escherichia coli at Oxidative and Nitrosative Stress

Expressed Soybean Leghemoglobin: Effect on Escherichia coli at Oxidative and Nitrosative Stress

Nitric Oxide Implication in Potato Immunity to Phytophthora infestans via Modifications of Histone H3/H4 Methylation Patterns on Defense Genes

Physiological significance of pedospheric nitric oxide for root growth, development and organismic interactions

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