Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidants

Subramanian, M. S.; Sreejayan,; Devasagayam, T.P.A.; Singh, B. B.

doi:10.1016/0027-5107(94)90183-x

Cited by 170 publications

(84 citation statements)

References 28 publications

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“…However, the levels of curcumin recovered were below 10 À8 M, thus of an order of magnitude that is unlikely to exert pharmacological effects in the light of results obtained in experiments in which cells in vitro were exposed to curcumin (see e.g., Sharma, 1976;Kunchandy and Rao, 1990;Huang et al, 1991;Reddy and Lokesh, 1992;Tonessan and Greenhill, 1992;Subramanian et al, 1994;Plummer et al, 1999).…”

Section: Discussionmentioning

confidence: 98%

“…Other mechanisms by which curcumin may exert chemopreventive action are interference with the transcription of the enzyme cyclooxygenase-2 (COX-2) (Plummer et al, 1999), induction of apoptosis (Kuo et al, 1996;Kawamori et al, 1999) and antiangiogenesis (Arbiser et al, 1998). The concentrations of curcumin needed to exert these effects in cells in vitro, range from 5 to 50 mM (Sharma, 1976;Kunchandy and Rao, 1990;Huang et al, 1991;Tonessan and Greenhill, 1992;Reddy and Lokesh, 1992;Subramanian et al, 1994;Plummer et al, 1999). Little is known about the potential pharmacological efficacy of products of the metabolic conjugation and reduction of curcumin.…”

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confidence: 99%

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Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

et al. 2004

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Studies in vitro and in animal models of colorectal and hepatocellular cancers suggest that curcumin is an effective chemopreventive agent. In this pilot trial, we investigated whether oral administration of curcumin results in concentrations of the agent in normal and malignant human liver tissue, which are sufficient to elicit pharmacological activity. In total, 12 patients with hepatic metastases from colorectal cancer received 450 -3600 mg of curcumin daily, for 1 week prior to surgery. Levels of curcumin and its metabolites were measured by HPLC in portal and peripheral blood, bile and liver tissue. Curcumin was poorly available, following oral administration, with low nanomolar levels of the parent compound and its glucuronide and sulphate conjugates found in the peripheral or portal circulation. While curcumin was not found in liver tissue, trace levels of products of its metabolic reduction were detected. In patients who had received curcumin, levels of malondialdehyde-DNA (M 1 G) adduct, which reflect oxidative DNA changes, were not decreased in post-treatment normal and malignant liver tissue when compared to pretreatment samples. The results suggest that doses of curcumin required to furnish hepatic levels sufficient to exert pharmacological activity are probably not feasible in humans.

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Section: Discussionmentioning

confidence: 98%

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confidence: 99%

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

et al. 2004

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“…Curcumin, diferuloyl methane, is the yellow pigment extracted from turmeric, which is commonly used as a spice and a coloring reagent especially in curries. Curcumin is known to inhibit the lipid peroxidation as an antioxidant, oxidative DNA damage, the activities of lipoxygenases and cyclooxygenases (Subramanian et al, 1994;Ruby et al, 1995). Other reports demonstrated that curcumin inhibited AP-1 function and JNK activation (Shin et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells

Kim

Jhon²,

Lee³

2004

Exp Mol Med

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“…Curcumin also has antioxidant activity (Khan et al, 2012a). It is said to destroy oxygen free radicals (Subramanian et al, 1994;Ruby et al, 1995;Khan et al, 2012a).…”

Section: Introductionmentioning

confidence: 99%

Improving the fatty acid profile in egg yolk through the use of hempseed (Cannabis sativa), ginger (Zingiber officinale), and turmeric (Curcuma longa) in the diet of Hy-Line White Leghorns

Raza¹,

Chand²,

Khan³

et al. 2016

Arch. Anim. Breed.

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Abstract.A study was performed to examine the outcome of utilizing hempseed, ginger, and turmeric in the diet of Hy-Line White Leghorn on the fatty acid profile of egg yolk. Four experimental rations were offered to 60 laying hens: control (standard diet); 25 % hempseed (T1); 25 % hempseed and 2 % turmeric (T2); 25 % hempseed and 2 % ginger (T3). Thirty eggs per group were analysed on day 0, 15, and 30 after storage at room temperature. Individual and total fatty acids decreased significantly (P < 0.05) in the experimental groups by day 0, 15, and 30 compared to the control. By day 0, 15, and 30, total monounsaturated fatty acids, palmitoleic acid, and oleic acid decreased significantly (P < 0.05) in T3. In fresh eggs, polyunsaturated fatty acids (PUFAs) increased significantly in T2 and T3 and were lower in the control and T1 by day 15 and 30. The same trend was also found in linoleic, eicosadienoic, and arachidonic acid. Linolenic acid increased significantly (P < 0.05) in T2 and T3 by day 15 and 30. However, eicosatrienoic acid, eicosapentaenoic acid, and docosahexaenoic acid increased significantly (P < 0.05) in all treated groups compared to the control by day 15 and 30. By day 15 and 30, total ω-3 increased significantly in treated groups. In contrast to ω-3, ω-6 increased significantly in T2 and T3 by day 15 and 30, while their ratio decreased significantly in treated groups. From the results of the present study, it was concluded that the addition of hempseed at the level of 25 % combined with 2 % turmeric and ginger in the diet of Hy-Line White Leghorn layers improved the fatty acid profile of n-3 PUFA, ω-3, and ω-6 in egg yolk.

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Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidants

Cited by 170 publications

References 28 publications

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells

Improving the fatty acid profile in egg yolk through the use of hempseed (<i>Cannabis sativa</i>), ginger (<i>Zingiber officinale</i>), and turmeric (<i>Curcuma longa</i>) in the diet of Hy-Line White Leghorns

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Diminution of singlet oxygen-induced DNA damage by curcmin and related antioxidants

Cited by 170 publications

References 28 publications

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

Involvement of ROS and JNK1 in selenite-induced a poptosisin Chang liver cells

Improving the fatty acid profile in egg yolk through the use of hempseed (&lt;i&gt;Cannabis sativa&lt;/i&gt;), ginger (&lt;i&gt;Zingiber officinale&lt;/i&gt;), and turmeric (&lt;i&gt;Curcuma longa&lt;/i&gt;) in the diet of Hy-Line White Leghorns

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Improving the fatty acid profile in egg yolk through the use of hempseed (<i>Cannabis sativa</i>), ginger (<i>Zingiber officinale</i>), and turmeric (<i>Curcuma longa</i>) in the diet of Hy-Line White Leghorns