Diminution of bile flow and of liver uptake and biliary excretion of bromsulphthalein by aldosterone.

Effect of chronic administration of aldosterone on bile secretion, on liver cytochrome P-450, and on red blood cell sodium content.

“…We found, in previous experiments (Afifi 1974(Afifi , 1975a) a diminution of sodium biliary excretion in rabbits infused with aldosterone , probably due to weeks. There is a proliferation of the smooth endoplasmic reticulum (SER aldosterone has a direct effect on sodium pump since the aldosterone infusion in rabbits is followed by a rapid diminution of bile flow (Afifi 1974). More complicated is the correlation between liver enzyme induction and bile secretion.…”

“…The diminution of bile flow by aldosterone administration seems not easy to explain since both bile acids and sodium are decreased to the same extent. Concerning the modifications of bile acid transport by aldosterone, we found (Afifi 1974(Afifi , 1975a) that aldosterone infusion in rabbits inhibits the choleretic response to cholic acid, diminishes the plasma disappearance and the biliary excretion of this bile acid. Since the affinity of the hepatocytes to aldsterone is extremely high (97% of circulating aldosterone is taken up during the first passage through the liver (Bercovici and Mauvais-Jarvis (1972) ), the possibility of competition can be considered.…”