Diminished modulation of preparatory sensorimotor mu rhythm predicts attention-deficit/hyperactivity disorder severity

Huurne, Niels ter; Lozano-Soldevilla, Diego; Onnink, A. Marten H.; Kan, Cornelis C.; Buitelaar, Jan K.; Jensen, Ole

doi:10.1017/s0033291717000332

Cited by 18 publications

(19 citation statements)

References 48 publications

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“…*p < .05; **p < .01; ***p < .001. Mazaheri et al, 2014), spatial working memory (Gomarus, Wijers, Minderaa, & Althaus, 2009;Lenartowicz et al, 2014Lenartowicz et al, , 2016Missonnier et al, 2013), as well as spatial visual attention (ter Huurne et al, 2013;Ter Huurne et al, 2017;Vollebregt et al, 2016). Consistent with our results, alpha power deficits have been associated with inattentive symptoms, suggesting that this metric is sensitive to typical behavioral dysfunction in ADHD (Gomarus et al, 2009;Lenartowicz et al, 2014;Mazaheri et al, 2014;Ter Huurne et al, 2017).…”

Section: Alpha Power and Attentional Healthsupporting

confidence: 90%

“…This hypothesis is gaining momentum. A recent review (Lenartowicz et al., ) identified 12 published studies since 2009, spanning adult and child samples, to document weakened alpha power modulation during encoding in tasks of cued selective attention (Mazaheri et al., ; Yordanova, Kolev, & Rothenberger, ), visual interference (i.e., flanker)(Hasler et al., ; Heinrich et al., ; Mazaheri et al., ), spatial working memory (Gomarus, Wijers, Minderaa, & Althaus, ; Lenartowicz et al., , ; Missonnier et al., ), as well as spatial visual attention (ter Huurne et al., ; Ter Huurne et al., ; Vollebregt et al., ). Consistent with our results, alpha power deficits have been associated with inattentive symptoms, suggesting that this metric is sensitive to typical behavioral dysfunction in ADHD (Gomarus et al., ; Lenartowicz et al., ; Mazaheri et al., ; Ter Huurne et al., ).…”

Section: Discussionmentioning

confidence: 99%

“…Evidence from brain oscillations suggests that attention processes play an important role in WM impairments in ADHD (Lenartowicz, Mazaheri, Jensen, & Loo, ). Modulation of power in the alpha band (8–12 Hz) during stimulus processing, a marker of visual perception and attention (Foxe & Snyder, ), has been shown to be attenuated in both children (Lenartowicz et al., ; Mazaheri et al., ; Vollebregt, Zumer, Ter Huurne, Buitelaar, & Jensen, ) and adults with ADHD (Hasler et al., ; Missonnier et al., ; Ter Huurne et al., ). In the study of Lenartowicz et al.…”

Section: Introductionmentioning

confidence: 99%

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Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD

Lenartowicz

Truong

Salgari

et al. 2019

Child Psychology Psychiatry

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Background Attention‐deficit/hyperactivity disorder (ADHD) is associated with working memory (WM) deficits. However, WM is a multiprocess construct that can be impaired through several pathways, leaving the source of WM impairments in ADHD unresolved. In this study, we aim to replicate, in an independent sample, previously reported deficits in component processes of WM deficits in ADHD and expand to consider their implications for neurocognitive outcomes. Methods In 119 children (7–14 years old, 85 with ADHD), we used electroencephalography measures to quantify component processes during performance of a spatial working memory task. We quantified stimulus encoding using alpha range (8–12 Hz) power; vigilance by the P2 event‐related potential to cues; and WMmaintenance by occipital‐alpha and frontal‐theta (4–7 Hz) power. These measures were evaluated against metrics of executive function, ADHD symptoms, and academic achievement. Results Encoding alpha‐power decreases and cue P2 amplitude were attenuated in ADHD, whereas occipital‐alpha power during maintenance was significantly greater in ADHD, consistent with a compensatory response to weak encoding. Weak alpha modulation during encoding was associated with poorer reading comprehension and executive function, as well as enhanced ADHD symptoms. Previously reported effects in frontal‐theta power failed to replicate. Conclusions Stimulus encoding, a component process of WM coupled to alpha modulation, is impaired in ADHD, and, unlike WM maintenance or vigilance processes, has implications outside of the laboratory via a relationship with executive function, and, to a weaker extent, reading comprehension.

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Section: Alpha Power and Attentional Healthsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD

Lenartowicz

Truong

Salgari

et al. 2019

Child Psychology Psychiatry

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“…The link between alpha rhythms and ADHD may be expected to some degree, if one considers that the alpha rhythm has been used extensively in the electrophysiological characterization of attention (see review by Klimesch, Fellinger, & Freunberger, ; Klimesch, ). Indeed, studies have shown that ADHD patients manifest significant alpha rhythmic deficits during attention (Hasler et al., ; Mazaheri et al., ; Ter Huurne et al., , ; Vollebregt, Zumer, Ter Huurne, Buitelaar, & Jensen, ; Yordanova, Kolev, & Rothenberger, ), which, however, have also emerged during WM tasks (Lenartowicz et al., ).…”

Section: Discussionmentioning

confidence: 99%

Beta band oscillatory deficits during working memory encoding in adolescents with attention‐deficit hyperactive disorder

Zammit

Muscat

2019

Eur J of Neuroscience

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Attention‐deficit hyperactivity disorder (ADHD) is a neurobehavioural disorder, characterized by symptoms of inattention and/or hyperactivity/impulsivity, in addition to various cognitive deficits, including working memory impairments. This pathology arises from a complex constellation of genetic, structural and neurotransmission abnormalities, which give rise to the aberrant electrophysiological patterns evident in patients with ADHD. Among such, findings have consistently provided support in favour of weaker power across the beta frequency range. Evidence has also emerged that beta rhythmic decrements are linked to working memory encoding. The catecholaminergic modulation of both working memory and beta oscillations may suggest that the link between the two might be rooted at the neurotransmission level. Studies have consistently shown that ADHD involves significant catecholaminergic dysregulation, which is also supported by other clinical studies that demonstrate stimulant‐induced amelioration of ADHD symptomology. In this study, we explore the possible ways that might relate ADHD, working memory, beta rhythms and catecholaminergic signalling altogether by investigating the integrity of encoding‐relevant electroencephalographic beta rhythms in medication‐naïve and stimulant‐medicated adolescent patients. The aberrant parietal and frontal encoding‐related beta rhythm revealed in the ADHD patients together with a working memory (WM) deficit as observed herein was reversed by methylphenidate in the latter case but not with regard to the beta rhythm. This finding per se raises the issue of the role played by beta rhythms in the WM deficits associated with ADHD.

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“…Increasing awareness, planning, and purposeful actions cause the sensorimotor rhythm (12–15 Hz) to appear in the motor cortex [9]. Training the sensorimotor rhythm through neurofeedback has been hypothesized to improve inhibitory responses and control of attention in children with ADHD [10,11]. Focused attention or sustained mental effort causes beta-1 (13–21 Hz) and beta-2 activity (22–30 Hz) to be active in the prefrontal, frontal and central midline areas (p. 434) [9].…”

Section: Attention-deficit/hyperactivity Disordermentioning

confidence: 99%

Mind–Body Therapy for Children with Attention-Deficit/Hyperactivity Disorder

Herbert

Esparham

2017

Children

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Attention-deficit/hyperactivity disorder (ADHD) is pervasive among the pediatric population and new treatments with minimal adverse effects are necessary to be studied. The purpose of this article is to review current research studying mind–body therapies for treatment of children diagnosed with ADHD. Literature was reviewed pertaining to the effectiveness of movement-based therapies and mindfulness/meditation-based therapies for ADHD. Many positive effects of yoga, Tai Chi, physical activity, and meditation may significantly improve symptoms of ADHD among children.

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Diminished modulation of preparatory sensorimotor mu rhythm predicts attention-deficit/hyperactivity disorder severity

Cited by 18 publications

References 48 publications

Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD

Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD

Beta band oscillatory deficits during working memory encoding in adolescents with attention‐deficit hyperactive disorder

Mind–Body Therapy for Children with Attention-Deficit/Hyperactivity Disorder

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