2007
DOI: 10.1359/jbmr.070115
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Diminished Bone Formation During Diabetic Fracture Healing is Related to the Premature Resorption of Cartilage Associated With Increased Osteoclast Activity

Abstract: Histological and molecular analysis of fracture healing in normal and diabetic animals showed significantly enhanced removal of cartilage in diabetic animals. Increased cartilage turnover was associated with elevated osteoclast numbers, a higher expression of genes that promote osteoclastogenesis, and diminished primary bone formation.Introduction: Diminished bone formation, an increased incidence of nonunions, and delayed fracture healing have been observed in animal models and in patients with diabetes. Frac… Show more

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Cited by 227 publications
(223 citation statements)
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“…At [43,44] . Consistent with the in vitro findings, a histomorphometric analysis in streptozotocininduced DM mice showed increases in osteoclast numbers and expre ssion of osteoclastogenic mediators, including TNFα, MCSF, RANKL and vascular endothelial growth factor (VEGF)A [45] . Moreover, there were upregulations of PPARγ, aP2 and resistin mRNAs, as well as increases in lipiddense adipocytes in the bone marrow of these streptozotocininduced DM mice, whereas adipose tissues at other sites, such as liver and peripheral areas, were decreased [44] .…”
Section: Possible Mechanisms Of Dm-induced Osteoporosissupporting
confidence: 78%
“…At [43,44] . Consistent with the in vitro findings, a histomorphometric analysis in streptozotocininduced DM mice showed increases in osteoclast numbers and expre ssion of osteoclastogenic mediators, including TNFα, MCSF, RANKL and vascular endothelial growth factor (VEGF)A [45] . Moreover, there were upregulations of PPARγ, aP2 and resistin mRNAs, as well as increases in lipiddense adipocytes in the bone marrow of these streptozotocininduced DM mice, whereas adipose tissues at other sites, such as liver and peripheral areas, were decreased [44] .…”
Section: Possible Mechanisms Of Dm-induced Osteoporosissupporting
confidence: 78%
“…Some previous studies indicated a decrease in the number of osteoclasts in type 1 diabetic rodent (20)(21)(22). On the other hand, several groups have reported higher levels of TRAP activity and an increased number of osteoclasts was observed in type 1 diabetic rodent (23)(24)(25)(26). In this regard, this study aimed to investigate the potential effect of insulin on RANKL and OPG expression in osteoblasts for the purpose of investigating the effect of insulin on osteoclast differentiation.…”
Section: Discussionmentioning
confidence: 96%
“…17 Kronik hiperglisemi osteoblastların sentezini etkilemekte ve osteoklastların fonksiyonunu arttırmaktadır. 18 Ayrıca kalsiyum ve potasyum metabolizmasını değiştirmektedir. 19 Bu etkiler iyileşme fazında kemik formasyonunu azaltarak osteointegrasyon döneminde implant kayıplarına neden olabilmektedir.…”
Section: Discussionunclassified