Dimethylsulfoxide as a penetrant carrier of allergens through intact human skin

Perlman, Frank; Wolfe, H. F.

doi:10.1016/0021-8707(66)90026-8

Cited by 18 publications

(2 citation statements)

References 11 publications

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“…Surprisingly, 30% dimethyl sulfoxide (DMSO) did not have any penetration enhancement effect with respect to Atto Oxa12. However, even if 30% DMSO can improve the dermal penetration of small molecules, it has been shown to have no effect on the skin penetration of macromolecules. − …”

Section: Resultsmentioning

confidence: 99%

Polyglycerol-Based Thermoresponsive Nanocapsules Induce Skin Hydration and Serve as a Skin Penetration Enhancer

Osorio‐Blanco

Rancan

Klossek

et al. 2020

ACS Appl. Mater. Interfaces

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The use of penetration enhancers (chemical or physical) has been proven to dramatically improve the penetration of therapeutics. Nevertheless, their use poses great risks, as they can lead to permanent damage of the skin, reduce its barrier efficiency, and result in the intrusion of harmful substances. Among the most used skin penetration enhancers, water is greatly accepted because skin quickly recovers from its exposure. Nanocapsules (NCs) represent a promising combination of the carrier system and penetration enhancer because their water-containing void combined with their polymer-based shell can be used to induce high local skin hydration, while simultaneously aiding the transport of drugs across the skin barrier. In this study, NCs were synthesized with a void core of 100 nm in diameter, a thermoresponsive shell based on different ratios of poly(N-isopropylacrylamide) and poly(N-isopropylmethacrylamide) as thermoresponsive polymers, and dendritic polyglycerol as a macromolecular cross-linker. These NCs can shrink or swell upon a thermal trigger, which was used to induce the release of the entrapped water in a controlled fashion. The interactions and effects of thermoresponsive NCs on the stratum corneum of excised human skin were investigated using fluorescence microscopy, high-resolution optical microscopy, and stimulated Raman spectromicroscopy. It could be observed that the thermoresponsive NCs increase the amount of deuterated water that penetrated into the viable epidermis. Moreover, NCs increased the skin penetration of a high-molecular weight dye (Atto Oxa12 NHS ester, MW = 835 g/mol) with respect to formulations in water or 30% DMSO, emphasizing the features of the NCs as a skin penetration enhancer.

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Section: Resultsmentioning

confidence: 99%

Polyglycerol-Based Thermoresponsive Nanocapsules Induce Skin Hydration and Serve as a Skin Penetration Enhancer

Osorio‐Blanco

Rancan

Klossek

et al. 2020

ACS Appl. Mater. Interfaces

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“…studied the percutaneous absorption of the carcinogen benzidine and observed that DMSO enhances dermal penetration of benzidine. Perlman and Wolfe demonstrated that allergens of small molar mass such as penicillin‐G potassium are carried through human skin if dissolved in a 90 wt % DMSO solution. However, allergens of a molar mass larger than 3000 Da could not be shown to penetrate skin with DMSO.…”

Section: Introductionmentioning

confidence: 99%

Potential of DMSO as greener solvent for PES ultra‐ and nanofiltration membrane preparation

Evenepoel

Wen

Tsehaye

et al. 2018

J of Applied Polymer Sci

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In this article, the performance of polyethersulfone (PES) ultra‐ and nanofiltration membranes, prepared with the non‐toxic solvent dimethyl sulfoxide (DMSO), was investigated. The membranes were prepared by immersion precipitation via phase inversion. Experimental results proved that DMSO is a better alternative to N‐methyl‐2‐pyrrolidone (NMP) as solvent for PES ultrafiltration membranes as the membranes had a higher permeability and rejection of bovine serum albumin (BSA). An explanation was found based on experimental cloud point data and scanning electron microscopy images showing the morphology. The rejection of BSA and rose Bengal (RB) was proportional to the polymer concentration. On the contrary, the permeability decreased with increasing polymer concentration. For a casting thickness of 250 µm, an optimal balance between permeability and rejection of macromolecules for ultrafiltration was found at 24 wt % PES. The permeability was inversely proportional to the casting thickness, but a small decrease in rejection was observed when lowering the thickness. A good balance between permeability and rejection of RB was found, using a reference nanofiltration membrane of 28.5 wt % PES with 150 µm casting thickness. This membrane achieved a RB rejection of 95.3% and a pure water flux of 2.03 L m−2 h−1 bar−1. The membrane thickness and polymer concentration did not have a clear influence on the hydrophilicity of the membranes. It can be concluded that DMSO is a benign alternative as compared to traditional solvents such as NMP and also results in better PES membrane performances. DMSO is a perfectly suitable solvent for ultrafiltration applications and has potential to be used for nanofiltration applications. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46494.

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Sorptionsvermittler in der Biopharmazie

Ritschel

1969

Angewandte Chemie

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Die Absorption von Arzneistoffen hiingt von den chemisch-physikalischen Eigenschaften der Substamen ab. Mit Hive von , ,Sorptionsvermittlern" gelingt es, Arzneistoffe, die schwer, uberhaupt nicht oder nur langsam absorbierbar sind, in die Haut und in die Schleimhaut eindringen (penetrieren) oder h r c h diese hindurchdringen (permeieren) zu lassen. Die Suche nach derartigen Hilfstoffen sowie die Aufklarung ihrer Wirkungsprinzipien geh6ren in den Bereich der Biopharmazie.

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Dimethylsulfoxide as a penetrant carrier of allergens through intact human skin

Cited by 18 publications

References 11 publications

Polyglycerol-Based Thermoresponsive Nanocapsules Induce Skin Hydration and Serve as a Skin Penetration Enhancer

Polyglycerol-Based Thermoresponsive Nanocapsules Induce Skin Hydration and Serve as a Skin Penetration Enhancer

Potential of DMSO as greener solvent for PES ultra‐ and nanofiltration membrane preparation

Sorptionsvermittler in der Biopharmazie

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