Dimethylaminododecyl methacrylate inhibits Candida albicans and oropharyngeal candidiasis in a pH-dependent manner

Chen, Hui; Zhou, Yujie; Zhou, Xuedong; Liao, Binyou; Xu, Hockin H.K.; Chu, Chun Hung; Cheng, Lei; Ren, Biao

doi:10.1007/s00253-020-10496-0

Cited by 20 publications

(13 citation statements)

References 42 publications

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“…But when the pH is lower than 4, the number of yeasts harbored bacteria falls sharply. This may be due to the change in the cell wall structure and the surface electric charge of C. albicans under acidic conditions, such as the significant loss of the fibrillar layer, the increased exposure of chitin and β-glucans [26], and the change of zeta potential of C. albicans [27].…”

Section: Potential For H Pylori Residence Within C Albicans Vacuolesmentioning

confidence: 99%

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The cross-kingdom interaction between Helicobacter pylori and Candida albicans

et al. 2021

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Helicobacter pylori infection and transmission routesHelicobacter pylori is a gram-negative microaerophilic bacterium. The infection of H. pylori can increase the risk of gastric cancer which is the second leading cause of cancer death worldwide [1]. The World Health Organization's International Agency for Research on Cancer (IARC) has classified H. pylori as a type I (definite) carcinogen since 1994. H. pylori infection is a global health problem. In developed countries, its infection rate is 20% to 50%, while in developing countries, the infection rate of middle-aged people has reached 80% [2]. The fecaloral and the oral-oral routes are considered as the main transmission routes of H. pylori [3]. Nevertheless, only H. pylori genes have been detected in saliva and dental plaques, but culturable H. pylori has not been isolated yet in large quantities [4], indicating that there may be some new strategies of H. pylori to implement its transmission through oral cavity.Candida albicans, a dimorphic fungus, is one of the most common fungi in the human body [5]. It was noteworthy that C. albicans and H. pylori were abundant in certain human niches, such as the root canal necrotic pulp, stomach, duodenum, and vagina [6], suggesting that C. albicans may interact with H. pylori to promote the growth, spread, and infection of H. pylori in some nonadaptive condition, such as the oral cavity and vagina. The synergy between H. pylori and C. albicans in gastric diseasesH. pylori infection is positively correlated with yeast in gastric diseases [7]. A total of 36% gastric ulcers patients, 2% non-ulcerative dyspepsia patients, and 56% large-scale gastric ulcers (greater than 2 cm) patients with H. pylori have fungal co-colonization in the upper gastrointestinal tract, such as C. albicans and Candida krusei, indicating the strong relationship between fungi and H. pylori in ulcerative lesions [8]. C. albicans is highly correlated with H. pylori in gastric cancer, peptic ulcer, and chronic gastritis patients. The gastric ulcer patient with C. albicans and H. pylori in the stomach developed even larger ulcers. The presence of C. albicans was closely related to the prolongation of gastric diseases by the increase of healing time and persistence of clinical symptoms [9,10]. The strong positive correlation between C. albicans and H. pylori in the development of gastric diseases indicates their synergistic pathogenesis [7]. C. albicans may enhance the colonization, toxicity, and pathogenicity of H. pylori especially in gastrointestinal diseases through adhesion and the formation of a mixed species, like that C. albicans promotes the pathogenicity of other bacteria [11].

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Section: Potential For H Pylori Residence Within C Albicans Vacuolesmentioning

confidence: 99%

“…albicans under acidic conditions, such as the significant loss of the fibrillar layer, the increased exposure of chitin and β-glucans [ 26 ], and the change of zeta potential of C . albicans [ 27 ].…”

Section: Helicobacter Pylori Infection and Transmission Routesmentioning

confidence: 99%

The cross-kingdom interaction between Helicobacter pylori and Candida albicans

et al. 2021

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“…Zhou et al [92] developed a nanocomposite with remineralizing and antibacterial properties via nanoparti-cles of amorphous calcium phosphate (NACP) and dimethylaminohexadecyl methacrylate (DMAHDM). The composite inhibited root caries biofilms of Streptococcus mutans [93,94], Lactobacillus acidophilus, and Candida albicans [95,96] in a recurrent root caries model and protected dentin hardness. These novel composite resins might successfully inhibit root caries in the elderly, control subgingival plaque, and reduce microleakage [97].…”

Section: Antimicrobial Materialsmentioning

confidence: 99%

Dental Restorative Materials for Elderly Populations

et al. 2021

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The incidence of dental caries, especially root caries, has risen in elderly populations in recent years. Specialized restorative materials are needed due to the specific site of root caries and the age-related changes in general and oral health in the elderly. Unfortunately, the restorative materials commonly used clinically cannot fully meet the requirements in this population. Specifically, the antibacterial, adhesive, remineralization, mechanical, and anti-aging properties of the materials need to be significantly improved for dental caries in the elderly. This review mainly discusses the strengths and weaknesses of currently available materials, including amalgam, glass ionomer cement, and light-cured composite resin, for root caries. It also reviews the studies on novel anti-caries materials divided into three groups, antimicrobial, remineralization, and self-healing materials, and explores their potential in the clinical use for caries in the elderly. Therefore, specific restorative materials for caries in the elderly, especially for root caries, need to be further developed and applied in clinical practice.

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“…However, here also the surface charge of the cells should be taken into consideration. Indeed, a study by Chen and co-workers showed that C. albicans cells have a more negative global charge at pH 7.4, of -26 mV, than at pH 5.2 (-15 mV) [62]. In our case, it can thus mean that the decreased adhesion forces recorded at pH 7.4 are due to the increased electrostatic repulsion with the negatively charged bubbles.…”

Section: Figure 5 Characterization Of the Interactions Between Bubbles And C Albicans Cells Schematic Representation Of A) Bubble -C Albimentioning

confidence: 45%