Dimethyl sulphoxide administration decreases renal ischemic–reperfusion injury

Identification of an Adamantyl Azaquinolone JNK Selective Inhibitor

“…This formulation allowed a larger set of analogs to be studied. However, DMSO itself can have protective effects on the kidney in rodent models of AKI, and thus, its use could confound the interpretation of results obtained in disease models. , The DMSO based formulation was replaced with an amorphous formulation, MBP (microprecipitated bulk powder) . The PK experiments performed with 4 in rats and mice using the DMSO-based and MBP formulations are shown in Table .…”