Dimethyl Sulfoxide Prevents Radiation-Induced Oral Mucositis Through Facilitating DNA Double-Strand Break Repair in Epithelial Stem Cells

Yang, Chao; Tang, Hongwei; Wang, Limei; Peng, Renjun; Bai, Fan; Shan, Ya-Jun; Yu, Zhen; Zhou, Pingkun; Cong, Yang

doi:10.1016/j.ijrobp.2018.07.2010

Cited by 18 publications

(20 citation statements)

References 33 publications

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“…Recently, several studies also indicate that DMSO acts to facilitate the repair of DNA damage [ 26 , 49 , 59 , 67 ]. Radioprotection due to the presence of DMSO is manly from the facilitation of DNA damage repair rather than through the suppression of indirect actions [ 26 , 49 ]. Bajinskis et al (2013) reported that DMSO affects primarily on all DNA repair pathways [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

“…Bajinskis et al (2013) reported that DMSO affects primarily on all DNA repair pathways [ 59 ]. Yang et al suggested that DMSO may facilitate the DSB repair pathways only [ 26 ]. Our study showed that the mutation probabilities of BER and NER pathways for 60 Co γ-rays, proton ions and high-LET helium ions were all respectively reduced by 35–39%, 43–48% and 16–31% in the presence of 2 M DMSO, indicating that DMSO might also alleviate the BER and NER repair pathways.…”

Section: Discussionmentioning

confidence: 99%

“…DMSO and radiosensitizers both have been used in RT for decades [ 55 , 68 ]. DMSO has been used to reduce the side effects in RT, in in vitro [ 41 , 52 , 53 , 58 ] and in vivo studies [ 26 , 69 ]. We have not found any clinical trial that uses DMSO during RT.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the combined use of DMSO in normal cells along with radiosensitizers increases the difference in the yields of DSB induction. The protective effects of DMSO can reduce complications for surrounding normal cells induced by a single dose in the tumor area [ 73 ] or fractioned doses applied on the head [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…Monte Carlo simulations and experiments also demonstrated that DMSO reduces the mutation frequency and increases the probability of correct repair [ 24 , 25 ]. Besides, DMSO can be used in RT to reduce the side effects [ 26 ].…”

Section: Introductionmentioning

confidence: 99%

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The Effects of Dimethylsulfoxide and Oxygen on DNA Damage Induction and Repair Outcomes for Cells Irradiated by 62 MeV Proton and 3.31 MeV Helium Ions

Chan

Hsiao

2021

JPM

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Reactive oxygen species (ROS) play an essential role in radiation-induced indirect actions. In terms of DNA damage, double strand breaks (DSBs) have the greatest effects on the repair of DNA damage, cell survival and transformation. This study evaluated the biological effects of the presence of ROS and oxygen on DSB induction and mutation frequency. The relative biological effectiveness (RBE) and oxygen enhancement ratio (OER) of 62 MeV therapeutic proton beams and 3.31 MeV helium ions were calculated using Monte Carlo damage simulation (MCDS) software. Monte Carlo excision repair (MCER) simulations were used to calculate the repair outcomes (mutation frequency). The RBE values of proton beams decreased to 0.75 in the presence of 0.4 M dimethylsulfoxide (DMSO) and then increases to 0.9 in the presence of 2 M DMSO while the RBE values of 3.31 MeV helium ions increased from 2.9 to 5.7 (0‒2 M). The mutation frequency of proton beams also decreased from 0.008‒0.065 to 0.004‒0.034 per cell per Gy by the addition of 2 M DMSO, indicating that ROS affects both DSB induction and repair outcomes. These results show that the combined use of DMSO in normal tissues and an increased dose in tumor regions increases treatment efficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effects of Dimethylsulfoxide and Oxygen on DNA Damage Induction and Repair Outcomes for Cells Irradiated by 62 MeV Proton and 3.31 MeV Helium Ions

Chan

Hsiao

2021

JPM

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Radioprotectors, Radiomitigators, and Radiosensitizers

Montoro,

Obrador,

Mistry

et al. 2023

Radiobiology Textbook

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This chapter gives an overview of molecules and mechanisms able to intervene with the biological effects of ionizing radiation (IR), either related to their clinical use in radiotherapy or in the field of radiation protection in case of an accidental exposure to radiation and/or nuclear emergencies. According to the National Cancer Institute, “radiomodifiers” can be classified into (a) radioprotectors (protect molecules and tissues from direct and indirect damage induced by IR) or (b) radiomitigators (reduce and help to repair damage), depending on whether they are administered pre- or post-IR exposure, respectively. Most of them are free radical scavengers and antioxidants (or enhancers of the antioxidant defenses), increase DNA repair mechanisms, have anti-inflammatory properties, and/or prevent cell death. On the other hand, (c) radiosensitizers directly or indirectly enhance DNA damage and ROS production, increasing IR toxicity on tumor cells, thus they are used to increase radiotherapy efficacy in cancer patients. The section “Radionuclides and methods to treat contaminated individuals” describes the medical consequences and treatment modalities of internal contamination by radionuclides. Overall, the chapter discusses the effects of most currently known radiomodifiers, their specific properties, and their mechanisms of action, by emphasizing results obtained in recent preclinical and clinical trials.

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Dimethyl sulfoxide, a potent oral radioprotective agent, confers radioprotection of hematopoietic stem and progenitor cells independent of apoptosis

Peng¹,

Zhang²,

Zuo³

et al. 2020

Free Radical Biology and Medicine

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Dimethyl Sulfoxide Prevents Radiation-Induced Oral Mucositis Through Facilitating DNA Double-Strand Break Repair in Epithelial Stem Cells

Cited by 18 publications

References 33 publications

The Effects of Dimethylsulfoxide and Oxygen on DNA Damage Induction and Repair Outcomes for Cells Irradiated by 62 MeV Proton and 3.31 MeV Helium Ions

The Effects of Dimethylsulfoxide and Oxygen on DNA Damage Induction and Repair Outcomes for Cells Irradiated by 62 MeV Proton and 3.31 MeV Helium Ions

Radioprotectors, Radiomitigators, and Radiosensitizers

Dimethyl sulfoxide, a potent oral radioprotective agent, confers radioprotection of hematopoietic stem and progenitor cells independent of apoptosis

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