Dimethyl Sulfone; A Constituent of the Adrenal Gland

Pfiffner, J. J.; North, H.B.

doi:10.1016/s0021-9258(18)73237-7

Cited by 21 publications

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“…In 1966, DMSO 2 was reported to be present in normal human urine, and more recently, it was detected in blood, cerebrospinal fluid, brain, skin, sweat, and earwax (summarized in Table ). In cows, DMSO 2 is one of the compounds highly correlated across plasma and milk, and it is present in the adrenal gland . Interestingly, DMSO 2 has also been observed in the urine of rats, bobcats, and African wild dogs, as well as the urine and tail gland excretion of red deer. , …”

Section: The Presence Of Dimethyl Sulfone (Dmso2) In the Human Metabo...mentioning

confidence: 99%

“…In cows, DMSO 2 is one of the compounds highly correlated across plasma and milk, 5 and it is present in the adrenal gland. 6 Interestingly, DMSO 2 has also been observed in the urine of rats, 7 bobcats, 8 and African wild dogs, 9 as well as the urine and tail gland excretion of red deer. 10,11 The correlation between DMSO 2 and age has been demonstrated in several studies.…”

Section: The Presence Of Dimethyl Sulfone (Dmso 2 ) In the Human Meta...mentioning

confidence: 99%

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Metabolic Fingerprint of Dimethyl Sulfone (DMSO₂) in Microbial–Mammalian Co-metabolism

Slupsky

2014

J. Proteome Res.

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There is growing awareness that intestinal microbiota alters the energy harvesting capacity of the host and regulates metabolism. It has been postulated that intestinal microbiota are able to degrade unabsorbed dietary components and transform xenobiotic compounds. The resulting microbial metabolites derived from the gastrointestinal tract can potentially enter the circulation system, which, in turn, affects host metabolism. Yet, the metabolic capacity of intestinal microbiota and its interaction with mammalian metabolism remains largely unexplored. Here, we review a metabolic pathway that integrates the microbial catabolism of methionine with mammalian metabolism of methanethiol (MT), dimethyl sulfide (DMS), and dimethyl sulfoxide (DMSO), which together provide evidence that supports the microbial origin of dimethyl sulfone (DMSO2) in the human metabolome. Understanding the pathway of DMSO2 co-metabolism expends our knowledge of microbial-derived metabolites and motivates future metabolomics-based studies on ascertaining the metabolic consequences of intestinal microbiota on human health, including detoxification processes and sulfur xenobiotic metabolism.

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Section: The Presence Of Dimethyl Sulfone (Dmso2) In the Human Metabo...mentioning

confidence: 99%

Section: The Presence Of Dimethyl Sulfone (Dmso 2 ) In the Human Meta...mentioning

confidence: 99%

Metabolic Fingerprint of Dimethyl Sulfone (DMSO₂) in Microbial–Mammalian Co-metabolism

Slupsky

2014

J. Proteome Res.

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Anticonvulsant Activity of Sulfoxides and Sulfones

Merritt¹,

Putnam²,

Bywater³

1945

Arch NeurPsych

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Certain anticonvulsant sulfur compounds which were mentioned briefly in a previous pub-lication1 have been investigated in more detail. Interest in the possible anticonvulsant properties of the sulfoxides and sulfones was suggested by their structural similarity to the ketones, which had been found to have pronounced anticonvulsant activity.2 These structural relationships are illustrated by the formula for ethyl phenyl ketone (propiophenone), ethyl phenyl sulfoxide and ethyl phenyl sulfone: C2H5C-< / GH"-S-< > ait-S-<. Il x~I l^^//\Vo o 00 Propiophenone Ethyl phenyl Ethyl phenyl sulfoxide sulfoneThe sulfoxides and sulfones possess more desirable physical properties than the alkylaryl sulfides, which were also observed to possess anticonvulsant activity. Additional study of homologous sulfides was discontinued because of their undesirable odor and unsavory taste. Our interest in the sulfones was further stimulated by the observation that dimethyl sulfone occurs naturally.Thus, Pfiffner and North3 isolated it from adrenal gland extracts, while Ruzicka and co-workers4 reported its isolation from dried cattle From the

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Biological activity of sulfoxides and sulfones

Kalir

1993

PATAI'S Chemistry of Functional Groups

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Dimethyl Sulfone; A Constituent of the Adrenal Gland

Cited by 21 publications

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Metabolic Fingerprint of Dimethyl Sulfone (DMSO₂) in Microbial–Mammalian Co-metabolism

Metabolic Fingerprint of Dimethyl Sulfone (DMSO₂) in Microbial–Mammalian Co-metabolism

Anticonvulsant Activity of Sulfoxides and Sulfones

Biological activity of sulfoxides and sulfones

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Dimethyl Sulfone; A Constituent of the Adrenal Gland

Cited by 21 publications

References 0 publications

Metabolic Fingerprint of Dimethyl Sulfone (DMSO2) in Microbial–Mammalian Co-metabolism

Metabolic Fingerprint of Dimethyl Sulfone (DMSO2) in Microbial–Mammalian Co-metabolism

Anticonvulsant Activity of Sulfoxides and Sulfones

Biological activity of sulfoxides and sulfones

Contact Info

Product

Resources

About

Metabolic Fingerprint of Dimethyl Sulfone (DMSO₂) in Microbial–Mammalian Co-metabolism

Metabolic Fingerprint of Dimethyl Sulfone (DMSO₂) in Microbial–Mammalian Co-metabolism