Dimethyl fumarate exerts neuroprotection by modulating calcineurin/NFAT1 and NFκB dependent BACE1 activity in Aβ1-42 treated neuroblastoma SH-SY5Y cells

Rajput, Mithun Singh; Nirmal, Nilesh Prakash; Rathore, Devashish; Dahima, Rashmi

doi:10.1016/j.brainresbull.2020.08.024

Cited by 14 publications

(4 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The accumulation of amyloid beta peptides gets deposited in the brain as plaques, and the loss of cholinergic neurons leads to AD pathogenesis ( Rajput et al, 2020b ). Inhibition of cholinesterases (butyrylcholinesterase (BChE) and acetylcholinesterase (AChE)) that degrade neurotransmitters is crucial ( Moussa-Pacha et al, 2020 , Rajput et al, 2020a ). Phytochemicals from mango and its byproducts have been reported to have inhibitory potential for activities against neurotransmitters, acetylcholine, and degrading enzymes, AChE and BchE ( Temviriyanukul et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Phenolic content of Thai Bao mango peel and its in-vitro antioxidant, anti-cholinesterase, and antidiabetic activities

Thangsiri,

Suttisansanee,

Koirala

et al. 2024

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Phenolic content of Thai Bao mango peel and its in-vitro antioxidant, anti-cholinesterase, and antidiabetic activities

Thangsiri,

Suttisansanee,

Koirala

et al. 2024

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

“…Neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease, present a significant health challenge in industrialized countries. These diseases are characterized by microglial activation and subsequent neuroinflammatory responses ( Rajput et al, 2020 ; Singh and Devasahayam, 2020 ). The ethanolic extract of C. sappan has demonstrated neuroprotective and anti-cerebral ischemic effects in an experimental model ( Wan et al, 2019 ).…”

Section: Pharmacologymentioning

confidence: 99%

A comprehensive review of Shengdeng in Tibetan medicine: textual research, herbal and botanical distribution, traditional uses, phytochemistry, and pharmacology

Ma,

Li,

Wang

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

“Shengdeng”, a group of Tibetan medicines with diverse biological origins, has long been utilized in Tibet for the treatment of rheumatoid arthritis. It showcases remarkable efficacy in alleviating rheumatism, reducing swelling, and relieving pain. This study aimed to clarify the plant species used as “Shengdeng” and summarize their botanical distribution, traditional uses, phytochemistry, and pharmacology to promote its utilization and development. “Shengdeng” is derived from a remarkable collection of 14 plant species belonging to six distinct families. Extensive phytochemical investigations have led to the identification of 355 chemical constituents within “Shengdeng”. Pharmacological studies conducted on “Shengdeng” have revealed a wide range of beneficial properties, including antioxidant, anticancer, antimicrobial, antiviral, antiparasitic, anti-inflammatory, and anti-arthritic activities. Notably, flavonoids and triterpenoids emerge as the predominant groups among these constituents, contributing to the therapeutic potential and diverse applications of “Shengdeng”. The present review provides a concise summary of the recent advancements in textual research concerning the herbal and botanical distribution, traditional uses, phytochemistry, and pharmacological activities of “Shengdeng”. It is crucial to note that future research on “Shengdeng” should prioritize the analysis of its active ingredients and the establishment of rigorous quality standards. These aspects are essential for ensuring consistency, efficacy, and safety in its clinical application.

show abstract

“…According to recent review of food derived bioactive peptides on neuroprotective effect, pea peptides have not yet been investigated (Wang, Waterhouse, Waterhouse, Zheng, Su, & Zhao, 2021). A − is widely applied to induce or as a toxic agent to establish both in vitro (Alghazwi, Charoensiddhi, Smid, & Zhang, 2020;Rajput, Nirmal, Rathore, & Dahima, 2020;Sirin & Aslim, 2021) and in vivo (Zhang et al, 2019;Giacomeli, Izoton, Santos, Boeira, Jesse, & Haas, 2019) models for investigating neuroprotective effects. A − -induced oxidative damage in SH-SY5Y cells, human neuroblastoma, is one of the applications.…”

Section: Introductionmentioning

confidence: 99%

“…It causes the activation of several biochemical pathogenic mediators such as oxidative stress, which activate the pathogenesis of AD (Sirin & Aslim, 2021). To study neuroprotective effects, the cells are pretreated or preincubated with different concentrations of target samples, and then subsequently expose to 1-10 M of A − , which induce oxidative damage to the cells (Rajput, Nirmal, Rathore, & Dahima, 2020;Sirin & Aslim, 2021).…”

Section: Introductionmentioning

confidence: 99%

Novel neuroprotective peptides derived from enzymatic hydrolysis of pea protein

Chiang

Hsu

2022

Preprint

View full text Add to dashboard Cite

The aim of this study was to purify and identify neuroprotective peptides derived from Flavourzyme ® -pea protein hydrolysate (FPPH). Cell viability of β-amyloid peptide (Aβ 1−42 )-induced oxidative damage in SH-SY5Y cells was used to explore neuroprotective effects of pretreating the cells with or without hydrolysate and its fractions. The higher cell viability represents the better neuroprotective effect. The hydrolysate was sequentially purified by gel filtration (GF) chromatography, reversed-phase (RP) chromatography and cation-exchange (CE) chromatography to explore any fraction to increase neuroprotective effects. The peptides were identified using a liquid chromatography tandem mass spectrometer (LC/MS/MS). Three novel neuroprotective peptides were obtained, and the amino acid sequences were NKFGKFF, GGPFKSPF and RPVLGGSSTFPYP. The in vitro effect of gastrointestinal proteases on neuroprotective effects of the three peptides were 23 also investigated. The result suggested that the gastrointestinal protease did 24 not affect neuroprotective effects of the three novel peptides, which reveal the 25 potential to ameliorate disease caused by neurodegeneration.

show abstract

Dimethyl fumarate exerts neuroprotection by modulating calcineurin/NFAT1 and NFκB dependent BACE1 activity in Aβ1-42 treated neuroblastoma SH-SY5Y cells

Cited by 14 publications

References 53 publications

Phenolic content of Thai Bao mango peel and its in-vitro antioxidant, anti-cholinesterase, and antidiabetic activities

Phenolic content of Thai Bao mango peel and its in-vitro antioxidant, anti-cholinesterase, and antidiabetic activities

A comprehensive review of Shengdeng in Tibetan medicine: textual research, herbal and botanical distribution, traditional uses, phytochemistry, and pharmacology

Novel neuroprotective peptides derived from enzymatic hydrolysis of pea protein

Contact Info

Product

Resources

About