2021
DOI: 10.1007/s12015-020-10094-7
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Dimethyl Fumarate Can Enhance the Potential Therapeutic Effects of Epidermal Neural Crest Stem Cells in COVID-19 Patients

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Cited by 5 publications
(5 citation statements)
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References 10 publications
(13 reference statements)
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“…The topic of different DMT classes and their effect on COVID-19 course and hospitalization risk remains a controversial one. We found low dose interferons and dimethyl fumarate to have significantly lower relative risks in comparison with rituximab, findings that have been supported by other observations of high sample size in case of interferon by Sormani et al ( Sormani et al, 2021 ) and mechanistic predictions in case of dimethyl fumarate by Timpani et al ( Timpani and Rybalka, 2020 ) and Safari et al ( Safari et al, 2021 ). Although numerous studies and reviews have founds rituximab to have a worse effect on COVID-19 course compared to various DMTs ( Chaudhry et al, 2021 ) ( Sormani et al, 2021 ) ( LangerGould et al, 2021 ) ( Safavi et al, 2020 ), a recent review by Sharifian-Dorche et al does not support such an association ( SharifianDorche et al, 2021 ) which shows the need for further studies and more thorough investigation of accumulated data.…”
Section: Discussionsupporting
confidence: 89%
“…The topic of different DMT classes and their effect on COVID-19 course and hospitalization risk remains a controversial one. We found low dose interferons and dimethyl fumarate to have significantly lower relative risks in comparison with rituximab, findings that have been supported by other observations of high sample size in case of interferon by Sormani et al ( Sormani et al, 2021 ) and mechanistic predictions in case of dimethyl fumarate by Timpani et al ( Timpani and Rybalka, 2020 ) and Safari et al ( Safari et al, 2021 ). Although numerous studies and reviews have founds rituximab to have a worse effect on COVID-19 course compared to various DMTs ( Chaudhry et al, 2021 ) ( Sormani et al, 2021 ) ( LangerGould et al, 2021 ) ( Safavi et al, 2020 ), a recent review by Sharifian-Dorche et al does not support such an association ( SharifianDorche et al, 2021 ) which shows the need for further studies and more thorough investigation of accumulated data.…”
Section: Discussionsupporting
confidence: 89%
“…Currently, the most widely used Nrf2 activator is the fumaric acid ester dimethyl fumarate (DMF) (Robledinos-Anton et al 2019 ; Safari et al 2021 ). DMF is a potent antioxidant and anti-inflammatory drug that modulates inflammation and oxidative stress, and hence cytoprotection, by upregulating cellular defense mechanisms, such as the expression of phase II antioxidants.…”
Section: Nrf2 Activators For Potential Therapy Of Covid-19mentioning
confidence: 99%
“…92 Another activator of Nrf2, fumaric acid ester DMF, can also inhibit NF-kB signalling, which is activated through the ACE2 locus. 93,94 Hence, DMF can be one of the that resulted in the inhibition of viral translation by making the SARS-CoV2 5 0 UTR susceptible to NSP1 suppression. 54 Similarly, NSP1 can also be targeted as it is one of the key proteins required for host translation inhibition, as shown in Figure 3A, and it is also known to regulate the immune response.…”
Section: Molecular Machineries As a Therapeutic Targetmentioning
confidence: 99%
“…PB125, an Nrf2 activator, is known to decrease expression of both ACE2 and TMPRSS2, thus inhibiting viral entry 92 . Another activator of Nrf2, fumaric acid ester DMF, can also inhibit NF‐kB signalling, which is activated through the ACE2 locus 93,94 . Hence, DMF can be one of the potent drugs to inhibit viral infection by promoting antioxidant activity and inhibiting the release of pro‐inflammatory cytokines.…”
Section: Molecular Machineries As a Therapeutic Targetmentioning
confidence: 99%