Abstract:A library of more than 2’500 plant extracts were screened for their activity on oncogenic signaling in melanoma cells. The ethyl acetate extract from aerial parts of Artemisia argyi displayed pronounced inhibition of the PI3K/AKT pathway. Active compounds were tracked with the aid of HPLC-based activity profiling, and a total of 21 active compounds were isolated, including one novel dimerosequiterpenoid (1), one new disesquiterpenoid (2), three new guaianolides (3-5), 12 known sesquiterpenoids (6-17), as well … Show more
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