Dimeric sialyl-Lex expression in gastric carcinoma correlates with venous invasion and poor outcome

Amado, Margarida; Carneiro, Fátima; Seixas, Mário; Clausen, Henrik; Sobrinho‐Simöes, Manuel

doi:10.1016/s0016-5085(98)70529-3

Cited by 95 publications

(70 citation statements)

References 23 publications

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“…Regarding the relationship between SLX positivity and histologic type, only a few studies have been found in English literatures, and yielded conflicting results (Dohi et al, 1989;Ikeda et al, 1996;Nakamori et al, 1997;Ura et al, 1997;Amado et al, 1998). In the present study, the frequency of SLX positivity was significantly higher among patients with differentiated carcinoma than among those with undifferentiated carcinoma (P < 0.0001).…”

Section: Discussioncontrasting

confidence: 57%

“…Previous studies regarding the significance of SLX expression in gastric carcinoma are limited and have yielded conflicting results (Nakamori et al, 1997;Ura et al, 1997;Amado et al, 1998). Nakamori et al (1997) reported that SLX expression in gastric carcinoma was not correlated with any clinicopathologic features.…”

Section: Discussionmentioning

confidence: 99%

“…Nakamori et al (1997) reported that SLX expression in gastric carcinoma was not correlated with any clinicopathologic features. However, Ura et al (1997) reported that SLX expression correlated with increased risk of metastases and poor prognosis in gastric carcinoma, and Amado et al (1998) reported that SLX expression in gastric carcinoma was correlated with venous invasion and poor outcome. These studies did not adequately mention the differences based on the histologic types.…”

Section: Discussionmentioning

confidence: 99%

“…Information regarding the significance of SLX expression in gastric carcinoma is limited (Nakamori et al, 1997;Ura et al, 1997;Amado et al, 1998). These studies did not satisfactorily mention the differences based on the histologic types.…”

mentioning

confidence: 99%

“…In recent years, correlations between the expression of these carbohydrates and outcomes have been reported for various tumours, although some studies have yielded conflicting results (Nakagoe et al, 1993;Nakamori et al, 1993Nakamori et al, , 1997Narita et al, 1993;Ogawa et al, 1994;Jorgensen et al, 1995;Nakayama et al, 1995;Amado et al, 1998). Information regarding the significance of SLX expression in gastric carcinoma is limited (Nakamori et al, 1997;Ura et al, 1997;Amado et al, 1998).…”

mentioning

confidence: 99%

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Clinicopathologic significance of sialyl Le xexpression in advanced gastric carcinoma

et al. 2000

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SummarySialyl Lewis x antigen (SLX) is a carbohydrate antigen that serves as a ligand for selectin, an adhesion molecule expressed on vascular endothelial cells. The expression of SLX in 245 patients with advanced gastric carcinoma was examined immunohistochemically, and its clinicopathologic significance was analysed. We classified the patients with advanced gastric carcinoma into 91 with differentiated type and 154 with undifferentiated type. SLX expressed in 135 of 245 patients (55%), comprising 68 (75%) patients with differentiated carcinoma and 67 (44%) with undifferentiated carcinoma. The positive rate for SLX expression was significantly higher among patients with differentiated carcinoma than among those in undifferentiated carcinoma (P < 0.0001). With differentiated carcinoma, the incidence of lymph node metastasis, advanced tumour stage (stage III and IV) and liver recurrence was significantly higher in SLX-positive patients than in SLXnegative ones (P < 0.0001, P = 0.0065 and P = 0.028, respectively). Moreover, the prognoses were better in patients with SLX-negative tumours than in those with SLX-positive tumours (P = 0.019). With undifferentiated carcinoma, there were no significant correlations between SLX expression and any clinicopathological features or prognoses. The clinicopathologic significance of SLX expression in gastric carcinoma patients depends on histologic type. SLX expression may be of great relevance in predicting liver metastases in patients with differentiated carcinoma.

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