Dimeric Matrine-Type Alkaloids from the Roots of <i>Sophora flavescens</i> and Their Anti-Hepatitis B Virus Activities

Zhang, Yubo; Zhan, Li-Qin; Li, Guoqiang; Wang, Feng; Wang, Ying; Li, Yao-Lan; Ye, Wen‐Cai; Wang, Guo‐Cai

doi:10.1021/acs.joc.6b00804

Cited by 61 publications

(44 citation statements)

References 38 publications

(102 reference statements)

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“…As an alternative approach, natural products have provided great promises as potentially effective antiviral drugs. A broad spectrum of phytochemicals including flavonoids such as wogonin and polyphenolics such as geraniin has been isolated and investigated for antihepatitis virus activities in vitro as well as in vivo [ 87 , 88 ]. The underlying action mechanisms have been proposed mainly as prevention of virus entry, inhibition of viral antigen secretion, and suppression of DNA replication [ 89 ].…”

Section: The Potential and Mechanism Of Action Of Polyphenols In Tmentioning

confidence: 99%

The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases

Tan

Wang

et al. 2018

Oxidative Medicine and Cellular Longevity

114

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Liver disease, involving a wide range of liver pathologies from fatty liver, hepatitis, and fibrosis to cirrhosis and hepatocellular carcinoma, is a serious health problem worldwide. In recent years, many natural foods and herbs with abundant phytochemicals have been proposed as health supplementation for patients with hepatic disorders. As an important category of phytochemicals, natural polyphenols have attracted increasing attention as potential agents for the prevention and treatment of liver diseases. The striking capacities in remitting oxidative stress, lipid metabolism, insulin resistance, and inflammation put polyphenols in the spotlight for the therapies of liver diseases. It has been reported that many polyphenols from a wide range of foods and herbs exert therapeutic effects on liver injuries via complicated mechanisms. Therefore, it is necessary to have a systematical review to sort out current researches to help better understand the potentials of polyphenols in liver diseases. In this review, we aim to summarize and update the existing evidence of natural polyphenols in the treatment of various liver diseases by in vitro, in vivo, and clinical studies, while special attention is paid to the action mechanisms.

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Section: The Potential and Mechanism Of Action Of Polyphenols In Tmentioning

confidence: 99%

The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases

Tan

Wang

et al. 2018

Oxidative Medicine and Cellular Longevity

114

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“…Matrine, which was approved by Chinese FDA (CFDA) in 1995, is derived primarily from Sophora species plants and has a chemical formula of C 15 H 24 N 2 O (5). Matrine exhibits a wide range of pharmacological effects and has long been applied to treat viral hepatitis (6), neuropathic pain (7), isoproterenol-induced cardiotoxicity inflammatory and other diseases (8,9). In addition, increasing evidence has revealed that matrine displays anticancer effects in various cancers, such as gastric (10), rhabdomyosarcoma (11), acute myeloid leukemia (12), osteosarcoma (13), prostate (14), breast (15) and lung cancer (16).…”

Section: Introductionmentioning

confidence: 99%

Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway

Zhou

Cai

2017

Oncology Reports

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Matrine is a traditional Chinese herbal medicine that shows antitumor efficacy for many types of cancer. The present study evaluated the antitumor efficacy of matrine on cervical cancer and to investigate the underlying mechanisms. We performed MTT assays, and in vitro invasion and migration assays, and P1 L6 found that matrine significantly inhibited cervical cancer cell growth by inducing apoptosis, and suppressed the invasion and migration ability of cervical cancer cells in vitro in a concentration-dependent manner. Mechanistically, we found that matrine decreased the expression and activity of the extracellular matrix factors, matrix metalloproteinases-2 (MMP-2) and MMP-9 via the suppression of p38 signaling pathway. In addition, when cervical cancer cells were grown as xenografts in nude mice, intraperitoneal (i.p.) injection of matrine induced a signiﬁcant dose-dependent decrease in tumor growth. Taken together, these findings suggest that a potential mechanism by which matrine inhibits the growth and metastasis of cervical cancer through downregulating the p38 signaling pathway.

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“…Matrine and its different derivatives were reported to have multiple effects in different disease models. For example, matrine can prevent bone loss [38], protect glial cells from central nervous system inflammation [39], alleviate intestinal inflammation [29], and decrease liver cell injury [40]. Additionally, it is reported that matrine showed very strong anti-tumor effect which includes cytotoxic effect on prostate tumor cells, bladder tumor cells, and breast cancer cells [31,41,42].…”

Section: Discussionmentioning

confidence: 99%

Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis

Seow

Wang

et al. 2019

Clinical Science

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Chronic Obstructive Pulmonary Disease (COPD) is a major incurable global health burden and will become the third largest cause of death in the world by 2030. It is well established that an exaggerated inflammatory and oxidative stress response to cigarette smoke (CS) leads to, emphysema, small airway fibrosis, mucus hypersecretion, and progressive airflow limitation. Current treatments have limited efficacy in inhibiting chronic inflammation and consequently do not reverse the pathology that initiates and drives the long-term progression of disease. In particular, there are no effective therapeutics that target neutrophilic inflammation in COPD, which is known to cause tissue damage by degranulation of a suite of proteolytic enzymes including neutrophil elastase (NE). Matrine, an alkaloid compound extracted from Sophora flavescens Ait, has well known anti-inflammatory activity. Therefore, the aim of the present study was to investigate whether matrine could inhibit CS-induced lung inflammation in mice. Matrine significantly reduced CS-induced bronchoalveolar lavage fluid (BALF) neutrophilia and NE activity in mice. The reduction in BALF neutrophils in CS-exposed mice by matrine was not due to reductions in pro-neutrophil cytokines/chemokines, but rather matrine’s ability to cause apoptosis of neutrophils, which we demonstrated ex vivo. Thus, our data suggest that matrine has anti-inflammatory actions that could be of therapeutic potential in treating CS-induced lung inflammation observed in COPD.

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Dimeric Matrine-Type Alkaloids from the Roots of Sophora flavescens and Their Anti-Hepatitis B Virus Activities

Cited by 61 publications

References 38 publications

The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases

The Potential and Action Mechanism of Polyphenols in the Treatment of Liver Diseases

Matrine inhibits the metastatic properties of human cervical cancer cells via downregulating the p38 signaling pathway

Matrine reduces cigarette smoke-induced airway neutrophilic inflammation by enhancing neutrophil apoptosis

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