Dimeric Manganese-Catalyzed Direct Nucleophilic Addition of C(sp²)–H Bonds to Inert Aldehydes

Abstract

An efficient direct nucleophilic addition reaction of C(sp2)–H bonds to aldehydes catalyzed by a dimeric manganese has been developed. This reaction has a broad range of substrates, and high yields were also obtained with inert aliphatic aldehydes as substrates. A dimeric Mn2(CO)8Br2 was proven to be a more efficient catalyst precursor than the monomeric Mn(CO)5Br.

Functionality‐Directed Regio‐ and Enantio‐Selective Olefinic C−H Functionalization of Aryl Alkenes

“…Alkenyl C−H activation occurs in D regenerates A with the liberation of CH 4 to close the catalytic cycle [9a] . Wang and co‐workers also disclosed a direct nucleophilic addition reaction of aromatic C−H bonds to aldehydes using dimeric Mn 2 (CO) 8 Br 2 as a catalyst [9b] …”