Dimeric immunoglobulin A as a novel diagnostic marker of measles infection
Khayriyyah Mohd Hanafiah,
Joanne Hiebert,
Vanessa Zubach
et al.
Abstract:Despite tremendous measles incidence reduction through universal vaccination, elimination efforts rely on improved surveillance. Detection of anti-measles immunoglobulin M (IgM) by ELISA is the standard laboratory diagnostic method. However, true infection is rare and seroconversion following MMR vaccination also generates IgM, which results in low positive predictive values of assays in elimination settings, thus necessitating confirmatory testing. Improved diagnostic tests for measles infection are a World H… Show more
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