2014
DOI: 10.1242/dev.099150
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Dimeric combinations of MafB, cFos and cJun control the apoptosis-survival balance in limb morphogenesis

Abstract: Apoptosis is an important mechanism for sculpting morphology. However, the molecular cascades that control apoptosis in developing limb buds remain largely unclear. Here, we show that MafB was specifically expressed in apoptotic regions of chick limb buds, and MafB/cFos heterodimers repressed apoptosis, whereas MafB/cJun heterodimers promoted apoptosis for sculpting the shape of the limbs. Chromatin immunoprecipitation sequencing in chick limb buds identified potential target genes and regulatory elements cont… Show more

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Cited by 27 publications
(22 citation statements)
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References 68 publications
(81 reference statements)
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“…A bird-specific CNE found 100 bp upstream from BMPR1B contains two transcription factor binding sites (TFBSs) for AP-1 (known as cJun ) and NF-E4 . The AP-1 transcription factor superfamily plays a role in the regulation of apoptosis during limb development in chickens (Suda et al 2014), and could account for the reported differences in expression of BMPR1B in birds compared to other vertebrates (Brawand et al 2011). Therefore, the presence of this CNE containing a relevant TFBS could have contributed to the formation and stability of this msHSB in avian evolution.…”
Section: Resultsmentioning
confidence: 99%
“…A bird-specific CNE found 100 bp upstream from BMPR1B contains two transcription factor binding sites (TFBSs) for AP-1 (known as cJun ) and NF-E4 . The AP-1 transcription factor superfamily plays a role in the regulation of apoptosis during limb development in chickens (Suda et al 2014), and could account for the reported differences in expression of BMPR1B in birds compared to other vertebrates (Brawand et al 2011). Therefore, the presence of this CNE containing a relevant TFBS could have contributed to the formation and stability of this msHSB in avian evolution.…”
Section: Resultsmentioning
confidence: 99%
“…MAFB was a favorable candidate gene of NSOC. It belongs to the MAF family of transcription factors characterized by a typical bZip structure and acts as an important regulator during the development and differentiation of many organs and tissues including orofacial development (Dixon et al , ; Suda et al , ; Tsuchiya et al , ). It was expressed in both craniofacial ectoderm and neural crest‐derived mesoderm between E13.5 and E14.5 in mouse models.…”
Section: Discussionmentioning
confidence: 99%
“…This is not unexpected since c‐Jun has been linked to a variety of developmental processes. Most importantly, dimers of the AP‐1 transcription factor members, c‐Jun and MafB, play a role in the induction of apoptosis in developing chick limbs (Suda et al, ). c‐Jun has also been found to be a key component of the signaling pathway that leads to joint formation in developing limbs (Kan and Tabin, ).…”
Section: Discussionmentioning
confidence: 99%