Dimeric alumatranes as catalysts for trimethylsilylcyanation reaction

Kim, Yoseph; Lee, Kang Mun; Kim, So Han; Moon, Jung Hee

doi:10.1039/c7ra09851k

Cited by 12 publications

(12 citation statements)

References 49 publications

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“…However, EGFP‐PD‐L1 lentiviral transduction dramatically elevated PD‐L1 expression in the DC PDL1+ group (98.63 ± 0.92)% (Figure 1D,E). Moreover, DC PDL1+ maintained the phenotype of immature DC2.4, [ 19 ] such as the presence of donor antigen H2Kb, CD86, low levels of CD80, and CD11c (Figure 1F), as seen previously. [ 3 ]…”

Section: Resultssupporting

confidence: 76%

Programmed Death Ligand‐1‐Overexpressing Donor Exosomes Mediate Donor‐Specific Immunosuppression by Delivering Co‐Inhibitory Signals to Donor‐Specific T Cells

Luo

Du²,

Long

et al. 2023

Adv Healthcare Materials

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Programmed death ligand‐1 (PD‐L1) and donor antigens are critical for donor immature dendritic cells (DCs) targeting donor‐specific T cells to induce transplant tolerance. This study aims to clarify whether DC‐derived exosomes (DEX) with donor antigens (H2b) and high levels of PD‐L1 expression (DEXPDL1+) can help to suppress graft rejection. In this study, it is demonstrated that DEXPDL1+ presents donor antigens, as well as PD‐L1 co‐inhibitory signals, directly or semi‐directly via DCs to H2b‐reactive T cells. This dual signal presentation can prolong the survival of heart grafts from B6 (H2b) mice but not from C3H (H2k) mice by inhibiting T cell activation, inducing activated T cell apoptosis, and modulating the balance of T cell differentiation from inflammatory to regulatory. Additionally, even though DEXPDL1+ treatment cannot induce tolerance after short‐term treatment, this study provides a new vehicle for presenting co‐inhibitory signals to donor‐specific T cells. This novel strategy may facilitate the realization of donor‐specific tolerance via the further optimization of drug‐loading combinations and therapeutic regimens to elevate their killing ability.

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Section: Resultssupporting

confidence: 76%

Programmed Death Ligand‐1‐Overexpressing Donor Exosomes Mediate Donor‐Specific Immunosuppression by Delivering Co‐Inhibitory Signals to Donor‐Specific T Cells

Luo

Du²,

Long

et al. 2023

Adv Healthcare Materials

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“…introduced the two cyclometalated Ir(III) complex‐based “off‐on” ECL chemodosimetric probes 17 – 18 for the selective recognition of sulfide (S 2− ) ions (Figure 6A). [50] These probes were designed with both reactive and quenching (PET) groups (e. g., (piq) 2 Ir(pic) (piq=1‐phenylisoquinoline, pic=picolinate)) that acted as the luminophore and the dinitrophenyl group moiety, respectively, for the selectivity and efficient sensing of sulfides with a high turn‐on ratio over other biological thiols and anions. The ECL intensities of probes 17 and 18 were enhanced by the PET process blocking from the Probe ligands.…”

Section: Sensing Gaseous Moleculesmentioning

confidence: 99%

Reaction‐Based Electrochemiluminescent Chemodosimeters for Reactive Species Detection in Biomedical Applications

Cheekatla,

Yoon,

Choi

et al. 2023

ChemElectroChem

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Electrochemiluminescence (ECL) probes are powerful molecular sensors that surpass the capabilities of conventional fluorescence or absorbance techniques. ECL offers distinct advantages, including exceptional photophysical properties, cost‐effectiveness, rapid response in sample analysis, high selectivity and sensitivity, ease of operation, portability, and high quantum yields. These advantages make ECL an ideal modality for quantifying biologically relevant species without disrupting regular cellular processes. The development of highly sensitive strategies for disease targets is of paramount importance in the fields of biological science and medicine. Furthermore, the increasing concerns surrounding the environment and health have resulted in the urgent need of discovering new sensors and biomarker detection approaches that are economically viable. Significant research has been conducted on chemosensors, called chemodosimeters, which utilize selective reaction‐based turn‐on phenomena. This review presents the research achievements in the design protocols, mechanisms, and recognition applications of various types of the reaction‐based ECL chemodosimeter. It specifically covers applications in the quantification of thiols, reactive oxygen‐nitrogen species (ROS/RNS), and gaseous signalling molecules. By shedding light on the ECL potential, we aim to inspire chemists and chemical biologists to explore novel strategies. These advancements will lead to the improved detection and visualization of biomedical targets.

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“…Viologens are n‐type organic molecules consisting of bi‐/multi‐pyridyl conjugated with a quaternary salt and are widely used as cathodic materials in many applications due to their stable two‐step reduction properties [29–32] . Because of the rapid development of functional materials in the twenty‐first century, viologens have been extensively integrated into a variety of novel and well‐known materials (e. g., host‐guest supramolecules, porous polymers, covalent‐ and metal‐organic frameworks) [33] .…”

Section: Introductionmentioning

confidence: 99%

A Novel Viologen‐Derived Covalent Organic Framework Based Metal Free Catalyst for Nitrophenol Reduction

Altınışık

Koyuncu

2023

ChemCatChem

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It is highly desirable to develop new metal free catalysts to reduction of toxic organic pollutants such as 4-nitrophenol (4-NP). Viologens are efficient electron-transfer mediators (ETMs) for reduction reactions with NaBH 4 as an effective hydrogen source. NaBH 4 -assisted reduction of 4-NP via a novel viologenbased covalent organic framework as metal free catalyst has been reported. The butyl bridge between the pyridine moieties at viologen based COF-TPCBP structure provides flexibility to the framework and gives the structure and amorphous character according to SEM, TEM and XRD results. The flexible 3D structure was also demonstrated by the geometric optimization. The structure without any metal moiety was fully completed to 4-NP reduction in only 12 minutes and have 88 % efficiency after 5 catalytic cycles because of the porous surface of the COF-TPCBP powder.

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Dimeric alumatranes as catalysts for trimethylsilylcyanation reaction

Abstract: First structurally characterized dimeric alumatranes with tricyclic five-membered rings were determined by single-crystal X-ray analysis and DFT calculations. New alumatranes were used as catalysts for trimethylsilycyanation reaction of aldehydes.

Cited by 12 publications

References 49 publications

Programmed Death Ligand‐1‐Overexpressing Donor Exosomes Mediate Donor‐Specific Immunosuppression by Delivering Co‐Inhibitory Signals to Donor‐Specific T Cells

Programmed Death Ligand‐1‐Overexpressing Donor Exosomes Mediate Donor‐Specific Immunosuppression by Delivering Co‐Inhibitory Signals to Donor‐Specific T Cells

Reaction‐Based Electrochemiluminescent Chemodosimeters for Reactive Species Detection in Biomedical Applications

A Novel Viologen‐Derived Covalent Organic Framework Based Metal Free Catalyst for Nitrophenol Reduction

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