Dimer-on-mirror SERS substrates with attogram sensitivity fabricated by colloidal lithography

Hakonen, Aron; Svedendahl, Mikael; Ogier, Robin; Yang, Zhong-Jian; Lodewijks, Kristof; Verre, Ruggero; Shegai, Timur; Andersson, Per Ola; Käll, Mikael

doi:10.1039/c5nr01654a

Cited by 96 publications

(71 citation statements)

References 63 publications

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“…Colloidal nanoparticles suspensions were one of the earliest SERS systems to demonstrate high sensitvity [8], however, these SERS surfaces depend on nanoparticle separation which determines the generation of hotspots. Other types of SERS substrates have been reported to produce enhancement factors of up to 10 11 [33]. The EF for Klarite R also seems rather low considering this type of SERS substrate is capable of producing EFs in the range of 10 6 [35], Rodrigues et al attribute this low enhancement to the fact that there is no strong hot spots in the SERS mapped area which leads to lower enhancements being measured.…”

Section: Simulations Of the Sers Effectmentioning

confidence: 92%

“…In [32] the Raman probe is 10 −2 M 4-mercaptopyridine, based on the vibrational band at 1090 cm −1 (for the nanosphere suspension the EF is based on the 1000 cm −1 band). 1,2-Bis(4-Pyridyl)Ethylene was used for dimer-on-mirror substrates, thionine acetate was used on gold-coated nanorod array, data extracted from [32][33][34]. [34] As indicated in Table 1, the shape, size and order of nanostructures can give orders of magnitude difference in SERS performance.…”

Section: Simulations Of the Sers Effectmentioning

confidence: 99%

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Surface Enhanced Raman Scattering Substrates Made by Oblique Angle Deposition: Methods and Applications

Chu

Song

et al. 2017

Coatings

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Surface Enhanced Raman Spectroscopy presents a rapid, non-destructive method to identify chemical and biological samples with up to single molecule sensitivity. Since its discovery in 1974, the technique has become an intense field of interdisciplinary research, typically generating >2000 publications per year since 2011. The technique relies on the localised surface plasmon resonance phenomenon, where incident light can couple with plasmons at the interface that result in the generation of an intense electric field. This field can propagate from the surface from the metal-dielectric interface, so molecules within proximity will experience more intense Raman scattering. Localised surface plasmon resonance wavelength is determined by a number of factors, such as size, geometry and material. Due to the requirements of the surface optical response, Ag and Au are typical metals used for surface enhanced Raman applications. These metals then need to have nano features that improve the localised surface plasmon resonance, several variants of these substrates exist; surfaces can range from nanoparticles in a suspension, electrochemically roughened electrodes to metal nanostructures on a substrate. The latter will be the focus of this review, particularly reviewing substrates made by oblique angle deposition. Oblique angle deposition is the technique of growing thin films so that the material flux is not normal to the surface. Films grown in this fashion will possess nanostructures, due to the atomic self-shadowing effect, that are dependent mainly on the deposition angle. Recent developments, applications and highlights of surface enhanced Raman scattering substrates made by oblique angle deposition will be reviewed.Keywords: surface enhanced Raman spectroscopy; coatings on polymer; special substrate materials; metal coatings; deposition, characterisations and applications of sculptured and textured thin films

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Section: Simulations Of the Sers Effectmentioning

confidence: 92%

Section: Simulations Of the Sers Effectmentioning

confidence: 99%

Surface Enhanced Raman Scattering Substrates Made by Oblique Angle Deposition: Methods and Applications

Chu

Song

et al. 2017

Coatings

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“…Raman EF of the SERS method were calculated for the new appeared peaks from an Analytical Chemistry point of view 47,48 according to the formula EF = (ISERS/NSERS) / (IRaman/NRaman), where ISERS and IRaman are, respectively, the signal intensities with and without silver substrate, NSERS the number of molecules responsible of enhancement (first layer in contact with silver, ~1.3·10 5 ) and NRaman the number of OBD-LDPE molecules in the detection volume (~3.0·10 8 ). The results are summarized in table 1.…”

Section: Please Do Not Adjust Marginsmentioning

confidence: 99%

Fast assessment of oxo-biodegradable polyethylene film oxidation by surface-enhanced Raman scattering with in situ formation of a silver nanoparticle substrate

2017

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“…18 The SERS intensity is distance dependent, and the target analyte has to be in very close proximity to the metal surface in order to generate enhanced scattering. 21 There are reports of the Raman scattering being enhanced as much as 10 11 22–23 . Additional enhancements can be achieved when the incident laser frequency and nanomaterial plasmon resonance match an electronic transition state of the absorbed molecule, similar to resonance Raman scattering (RRS), resulting in surface-enhanced resonance Raman scattering (SERRS).…”

Section: Introductionmentioning

confidence: 99%

Bioanalytical applications of surface-enhanced Raman spectroscopy: de novo molecular identification

Nguyen

Peters

Schultz

2017

Reviews in Analytical Chemistry

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Surface enhanced Raman scattering (SERS) has become a powerful technique for trace analysis of biomolecules. The use of SERS-tags has evolved into clinical diagnostics, the enhancement of the intrinsic signal of biomolecules on SERS active materials shows tremendous promise for the analysis of biomolecules and potential biomedical assays. The detection of the de novo signal from a wide range of biomolecules has been reported to date. In this review, we examine different classes of biomolecules for the signals observed and experimental details that enable their detection. In particular, we survey nucleic acids, amino acids, peptides, proteins, metabolites, and pathogens. The signals observed show that the interaction of the biomolecule with the enhancing nanostructure has a significant influence on the observed spectrum. Additional experiments demonstrate that internal standards can correct for intensity fluctuations and provide quantitative analysis. Experimental methods that control the interaction at the surface are providing for reproducible SERS signals. Results suggest that combining advances in methodology with the development of libraries for SERS spectra may enable the characterization of biomolecules complementary to other existing methods.

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Dimer-on-mirror SERS substrates with attogram sensitivity fabricated by colloidal lithography

Cited by 96 publications

References 63 publications

Surface Enhanced Raman Scattering Substrates Made by Oblique Angle Deposition: Methods and Applications

Surface Enhanced Raman Scattering Substrates Made by Oblique Angle Deposition: Methods and Applications

Fast assessment of oxo-biodegradable polyethylene film oxidation by surface-enhanced Raman scattering with in situ formation of a silver nanoparticle substrate

Bioanalytical applications of surface-enhanced Raman spectroscopy: de novo molecular identification

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