Dimensions of Niche-Induced Anti-Apoptosis of Therapeutically Resistant Neoplasms in Radio-Chemo-Therapy

Abstract

It is proposed that apoptotic linear progression schemes do not adequately account for the emergence of non-response in radio-chemoresistant neoplastic lesions. In such defining contributory patterns of activated and non-activated apoptosis there is emerging evidence for distributional programs sustained by networks of spatial distribution. Such a concept may well implicate angiogenic switches and origins of vessels and tumor cells from a resident stem cell population in the niche micro-environment. It is towards the realization of performance attributes of cell-cycle arrest on the one hand and of proliferative dysfunctionality that the resistance and relapse of tumors is exemplified by an integrated clonogenic phenomenon of cellular derivation and end-result as relapsed neoplasms.