Dimensions and histologic characteristics of the small intestine of dogs during postnatal development

Paulsen, Daniel B.; Buddington, Karyl K.; Buddington, Randal K.

doi:10.2460/ajvr.2003.64.618

Cited by 41 publications

(43 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several examples of Class II and III evidence‐based data were found in the Group's review of the scientific literature. Most of the studies employed microscopic evaluation of hematoxylin and eosin (HE) stained tissues, 21–23,35–39 whereas others used IHC to label and count leukocyte populations 11–13,40–48 . Representative examples from the GI Standardization Group's archives have been published already, 3 but summaries of studies in each anatomic area follow.…”

Section: Normal Histology Of the Gastrointestinal Tractmentioning

confidence: 99%

“…Several studies have evaluated the normal canine and feline duodenal mucosa with HE and immunohistochemical staining 43,47,49,50 . The normal villus length for an adult dog is 722 ± 170 μm, the normal crypt depth is 1,279 ± 203 μm, and the normal villus to crypt ratio is 0.7 ± 0.3 39,49,50 . Normal dogs have a mean number of 3.6 ± 3.6 goblet cells per stretch of 100 villous enterocytes, and 9.3 ± 3.1 goblet cells per stretch of 100 cryptal enterocytes 43 .…”

Section: Normal Histology Of the Gastrointestinal Tractmentioning

confidence: 99%

See 1 more Smart Citation

Endoscopic, Biopsy, and Histopathologic Guidelines for the Evaluation of Gastrointestinal Inflammation in Companion Animals

Washabau

Day

Willard

et al. 2010

Veterinary Internal Medicne

304

248

View full text Add to dashboard Cite

Section: Normal Histology Of the Gastrointestinal Tractmentioning

confidence: 99%

Section: Normal Histology Of the Gastrointestinal Tractmentioning

confidence: 99%

Endoscopic, Biopsy, and Histopathologic Guidelines for the Evaluation of Gastrointestinal Inflammation in Companion Animals

Washabau

Day

Willard

et al. 2010

Veterinary Internal Medicne

304

248

View full text Add to dashboard Cite

“…Furthermore, to fuel ontogenetic growth and provide the developing body with the tissue necessary for digestion and absorption of high dietary loads, the small intestine is relatively larger in juveniles. For example, Beagle puppies at PW9 have, relative to body mass, a small intestine that is 33% longer, weighs 45% more, has 40% more mucosa and 35% more surface area than adults (Paulsen et al, ). Taken together, the growth patterns of the inner organs and particularly of the small intestine are in accordance with a cranial shift of the limbs' support roles.…”

Section: Discussionmentioning

confidence: 99%

Ontogenetic change of the weight support pattern in growing dogs

et al. 2014

View full text Add to dashboard Cite

Weight support patterns vary widely among mammals. Differences in how much of the body weight is supported by the fore- versus the hind-limbs are well documented among and within species. Intraindividual variation due to ontogenetic processes has been studied in several hindlimb-dominated species and consistently showed a caudal shift in the limbs' support roles. We hypothesized that forelimb-dominated species exhibit a cranial shift in their support pattern and tested this hypothesis by examining the vertical ground reaction forces in growing dogs. Six male Beagle siblings were studied from 9 to 51 postnatal weeks (PW) of age while they trotted on an instrumented treadmill. Ontogenetic shifting in fore-to-hind support was evaluated using vertical force ratios (i.e., peak and impulse) as well as the stance time ratio of the fore- and the hind-limbs. Because morphological and kinematic characteristics influence weight support patterns, changes in body shape (i.e., trunk shape), and average limb position were determined. As in adult dogs, the forelimbs carried a greater proportion of the body weight than the hindlimbs at all ages. When the dogs were younger, peak vertical force occurred earlier during stance in the hindlimbs but not the forelimbs. Both the increasing ratio of the vertical force and the increasing ratio of the stance times indicate an increasing weight support by the forelimbs (i.e., 59% at PW9 vs. 63% at PW51). The observed ontogenetic changes in trunk shape and average limb angle were consistent with this cranial shift in weight support.

show abstract

“…Data on the histological changes in the intestinal morphology in dependence on physiological processes, however, are very sparse. Suckling puppies exhibit rapid changes in the mucosal morphology that reach a comparatively stable state by the 42 nd d of life [1] . In old dogs, Lafora body-like polyglucosan bodies have been described in the smooth musculature [2] and amyloid in the vessel walls of the large and small intestine without functional or neurological abnormalities [3] .…”

Section: Introductionmentioning

confidence: 99%

Age-related histomorphologic changes in the canine Gastrointestinal tract: A histologic and immunohistologic study

Baum

Meneses²,

Kleinschmidt³

et al. 2007

WJG

View full text Add to dashboard Cite

AIM:To examine the changes in the histomorphology of the gastric, jejunal and colonic wall of dogs due to physiological aging. METHODS:Full thickness biopsies were taken from the gastrointestinal tracts of 28 dogs of different ages. The thickness of the different layers of the wall was measured and the numbers of proliferating cells as indicated by immunohistochemical detection of Ki67 were counted. RESULTS:In the three excision sites, the thickness of all subepithelial layers increased with rising age. The strongest correlation between age and thickness of the intestinal wall was found in the first 10 years of life and in the jejunum (r = 0.6-0.71 for the deep lamina propria mucosa, the muscularis mucosa, and the circular layer of the tunica muscularis). The number of proliferating cells decreased during aging, with the strongest correlation in the lamina propria mucosa and lamina muscularis mucosa of the jejunum and in the colonic submucosa (r = -0.61 to -0.71). Epithelial proliferation was only weakly correlated to the age. CONCLUSION:The morphology of the deeper layers and the proliferation of mesenchymal cells of the intestinal wall of healthy dogs are correlated with age. Gastrointestinal epithelial proliferation is only weakly age-correlated.

show abstract

Dimensions and histologic characteristics of the small intestine of dogs during postnatal development

Cited by 41 publications

References 42 publications

Endoscopic, Biopsy, and Histopathologic Guidelines for the Evaluation of Gastrointestinal Inflammation in Companion Animals

Endoscopic, Biopsy, and Histopathologic Guidelines for the Evaluation of Gastrointestinal Inflammation in Companion Animals

Ontogenetic change of the weight support pattern in growing dogs

Age-related histomorphologic changes in the canine Gastrointestinal tract: A histologic and immunohistologic study

Contact Info

Product

Resources

About