Dimensional structure of the Hamilton Depression Rating Scale in patients with obsessive–compulsive disorder

Moritz, Steffen; Meier, Beat; Hand, Iver; Schick, Mildred; Jahn, Holger

doi:10.1016/j.psychres.2003.11.003

Cited by 44 publications

(20 citation statements)

References 23 publications

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“…While the number of factors identified ranges widely, there is strong support for the presence a 'core depression' factor and an 'anxiety' factor, as well as for a sleep disturbance factor. According to the results of a recent confirmatory factor analysis [23], which shared many similarities with a previous study by our group [24], the 'core depression' factor is loaded by items 1, 7 and 8 (depressed mood, work and activities, retardation), while the 'anxiety' factor is loaded by items 10, 11, and 15 (psychic anxiety, somatic anxiety, hypochondriasis). Hence, for the HDRS, we calculated the scores on these two subsets of items in addition to the total score for each time point.…”

Section: Methodssupporting

confidence: 72%

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Pasquini¹,

Picardi²,

Speca³

et al. 2007

Clin Pract Epidemiol Ment Health

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BackgroundSeveral patients with unipolar depression present with prominent dysphoric mood. We aimed at examining the effectiveness of the combination of an SSRI with an anticonvulsant in such patients.MethodsThirty-five newly admitted outpatients with substantial anger, irritability, aggressiveness or hostility who were diagnosed a DSM-IV unipolar depressive disorder were rated on the Hamilton Depression Rating Scale (HDRS), the Clinical Global Improvement (CGI) scale, and a scale for the rapid dimensional assessment (SVARAD), were prescribed an SSRI and an anticonvulsant (usually valproate), and were followed up for 12 weeks. Repeated measures analysis of variance was used to test for within-subject changes in scale scores over time.ResultsThirty-two and 23 patients attended the follow-up visits 4 and 12 weeks later, respectively. Significant decreases (p < .001) were observed in HDRS total score, HDRS and SVARAD anxiety factors, HDRS and SVARAD core depression factors, and SVARAD anger/irritability factor. Adjusting for age or gender did not change the results. Most patients (82%) were rated as improved or much improved on the CGI.ConclusionAlthough our study has several limitations, we observed a remarkable improvement in most unipolar depressed outpatients with dysphoric mood treated with an SSRI and an anticonvulsant. The effectiveness of anticonvulsants might be linked to their action on symptoms of aggression and behavioural activation.

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Section: Methodssupporting

confidence: 72%

Untitled

Pasquini¹,

Picardi²,

Speca³

et al. 2007

Clin Pract Epidemiol Ment Health

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“…We examined overall functioning from clinical scores on the Global Assessment of Function (GAF). Because symptoms of disturbed sleep and anxiety can represent distinct subtypes of major depression (Moritz et al, 2004),(Fawcett et al, 1990) and substance use disorders (Clark et al, 2001), we examined sleep disturbance and maternal anxiety subscales (Moritz et al, 2004),(Fawcett et al, 1990) from the SIGH-ADS and EPDS measures. For sleep disturbance we examined the SIGH-ADS sleep items on early, middle and late insomnia (items H6, H7 and H8), hypersomnia (item A6) and wake time after sleep onset (WASO) more than 20 minutes.…”

Section: Methodsmentioning

confidence: 99%

“…We constructed a categorical measure of insomnia (score of 2 on any of the 3 insomnia items), and a composite 6-point subscale for sleep (Clark et al, 2001; Fawcett et al, 1990) comprised of the SIGH-ADS sleep items plus EPDS item 7 “I’ve been so unhappy I’ve had difficulty sleeping”. We explored maternal anxiety symptoms (Wisner et al, 2013) with the SIGH-ADS items for anxiety: agitation, psychic anxiety, somatic symptoms, hypochondriasis and obsessive thoughts or compulsive behaviors (items H17, H12, H13, H14, and H21), and a composite 7-point anxiety subscale (Clark et al, 2001; Fawcett et al, 1990; Moritz et al, 2004) comprised of the SIGH-ADS anxiety items plus EPDS items 4 and 5, “I’ve been anxious or worried for no good reason and “I’ve felt scared or panicky for no very good reason”.…”

Section: Methodsmentioning

confidence: 99%

Suicidal ideation in depressed postpartum women: Associations with childhood trauma, sleep disturbance and anxiety

Sit

Luther

Buysse

et al. 2015

Journal of Psychiatric Research

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Background Suicide is one of the leading causes of death in postpartum women. Identifying modifiable factors related to suicide risk in mothers after delivery is a public health priority. Our study aim was to examine associations between suicidal ideation (SI) and plausible risk factors (experience of abuse in childhood or as an adult, sleep disturbance, and anxiety symptoms) in depressed postpartum women. Methods This secondary analysis included 628 depressed mothers at 4–6 weeks postpartum. Diagnosis was confirmed with the Structured Clinical Interview for DSM-IV. We examined SI from responses to the Edinburgh Postnatal Depression Scale-EPDS item 10; depression levels on the Structured Interview Guide for the Hamilton Depression Rating Scale, Atypical Depression Symptoms (SIGH-ADS); plus sleep disturbance and anxiety levels with subscales from the EPDS and SIGH-ADS items on sleep and anxiety symptoms.. Results Of the depressed mothers, 496 (79%) ‘never’ had thoughts of self-harm; 98 (15.6%) ‘hardly ever’; and 34 (5.4%) ‘sometimes’ or ‘quite often’. Logistic regression models indicated that having frequent thoughts of self-harm was related to childhood physical abuse (odds ratio-OR=1.68, 95% CI=1.00, 2.81); in mothers without childhood physical abuse, having frequent self-harm thoughts was related to sleep disturbance (OR=1.15, 95%CI=1.02, 1.29) and anxiety symptoms (OR=1.11, 95%CI=1.01, 1.23). Discussion Because women with postpartum depression can present with frequent thoughts of self-harm and a high level of clinical complexity, conducting a detailed safety assessment, that includes evaluation of childhood abuse history and current symptoms of sleep disturbance and anxiety, is a key component in the management of depressed mothers.

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“…The HDRS mean total score for OCD patients was 13.00 (SD 5 6.10). Following a previous factor analytic study conducted in OCD patients (Moritz et al, 2004b), the HDRS was split into four subscales (core depressive symptoms, anxiety, gastrointestinal problems, sleep). Exclusion criteria were a history of comorbid substance abuse, substantial neurological disorder (e.g., multiple sclerosis, traumatic brain injury), and current or previous psychotic symptoms.…”

Section: Introductionmentioning

confidence: 99%

Everyday memory functioning in obsessive– compulsive disorder

Jelinek

Moritz

Heeren

2006

J Int Neuropsychol Soc

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Memory performance in obsessive-compulsive disorder (OCD) is discussed as a pathogenetic risk factor for the emergence of OCD, particularly checking compulsions. At present, however, findings are mixed and little is known about memory performance in tasks relevant to everyday functioning in patients with OCD. For the present study, memory performance was assessed in 31 patients diagnosed with OCD and 33 healthy controls with the Rivermead Behavioural Memory Test (RBMT), which covers a wide range of verbal and nonverbal memory components as well as prospective memory. OCD patients performed comparably to healthy controls on the memory task for verbal, nonverbal, and prospective memory (p > .1). According to norm values, memory performance was unimpaired in most OCD patients. The present findings further challenge a broad account of the "memory deficit" hypothesis of OCD and compulsive checking, respectively.

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Dimensional structure of the Hamilton Depression Rating Scale in patients with obsessive–compulsive disorder

Cited by 44 publications

References 23 publications

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Suicidal ideation in depressed postpartum women: Associations with childhood trauma, sleep disturbance and anxiety

Everyday memory functioning in obsessive– compulsive disorder

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