Dillenia suffruticosa exhibited antioxidant and cytotoxic activity through induction of apoptosis and G2/M cell cycle arrest

Abstract

It is suggested that the cytotoxicity of the active extracts in HeLa was due to the induction of apoptosis and cell cycle arrest at G2/M.

Phenolic content and antioxidant activity of cactus (Opuntia ficus-indica L.) flowers are modified according to the extraction method

“…Similar results for the O. ficus-indica f. inermis flowers reported the presence of TPC (159.76 mg GAE/g of extract) and yielded 23.64% (Alimi et al, 2011). Opuntia flowers contained rich amount of polyphenols comparing to Alpinia zerumbet and Dillenia suffruticosa flowers (Armania et al, 2013;Elzaawely et al, 2007). But also many investigations showed higher TPC in flowers, compared to Opuntia flowers (Barreira et al, 2008;Ho et al, 2007).…”

Total Phenolic Content, Antioxidant, Cytotoxicity and Hepatoprotective Activities of Aqueous Extract of Channa striatus (Haruan)

“…The method was conducted based on the procedure described [15]. The DPPH stock solution was prepared by mixing 2.1 mg of DPPH powder in 50 ml of methanol.…”

Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway

“…This plant has been reported to exhibit antimicrobial (Wiart et al, 2004) and antiviral properties (Muliawan, 2008). Our previous studies reported that the root dichloromethane extract of D. suffruticosa (DCM-DS) from sequential solvent extraction was the most cytotoxic towards breast cancer cells as compared to hexane, ethyl acetate and methanol extract (Armania et al, 2013a). DCM-DS induced G 0 /G 1 phase cell cycle arrest and apoptosis towards human caspase-3 deficient MCF-7 breast cancer cells by modulating the expression of mitogen-activated protein kinases (MAPKs) and protein kinase B (PKB or AKT) at gene and protein level Tor et al, 2014;Armania et al, 2013b).…”