A direct CP asymmetry in inclusive semileptonic B (s) decays vanishes by CPT to lowest order in weak interactions. Calculating the asymmetry at second order weak interactions in the Cabibbo-Kobayashi-Maskawa framework we find A sl = (−3.2 ± 0.9) × 10 −9 . A maximal asymmetry which is two orders of magnitude larger is estimated in a left-right symmetric model. This quite generic upper bound implies negligible effects on wrong-sign lepton asymmetries in B 0 and B s decays.