Dilated Cardiomyopathy: A Paradigm of Revolution in Medicine

Abstract

Dilated Cardiomyopathy (DCM) has a straightforward and apparently “simple” definition: a heart muscle disease characterized by left ventricular (LV) or biventricular dilation and systolic dysfunction in the absence of either pressure or volume overload or coronary artery disease sufficient enough to explain the dysfunction [...]

Association of Genetic Variants With Outcomes in Patients With Nonischemic Dilated Cardiomyopathy

“…Such genetic heterogeneity likely contributes to the variable phenotypes and expressivity observed in DCM. Indeed, there is growing evidence that the clinical course depends on the underlying affected gene (2)(3)(4)(5).…”

Bioinformatics-Based Identification of lncRNA-miRNA-mRNA Network in Dilated Cardiomyopathy and Drug Prediction

“…The diversity of pathways in which it is involved corresponds to its various pathogenic factors such as cardiotoxic compounds, metabolism, rheumatological and endocrine diseases, and cellular infiltration and viral infection [16]. Due to multiple heterogeneous etiologies, dilated cardiomyopathy is an "umbrella" term that describes the final common pathway of different pathogenic processes and gene-environment interactions [17]. A further accurate understanding of the molecular mechanisms and signaling pathways of DCM caused by various etiologies facilitates further subdivision of DCM, which is of great significance for targeted therapy and prognosis of DCM.…”

Echocardiographic assessment of patients with dilated cardiomyopathy (DCM) depending on the systolic function of the right ventricle assessed by cardiovascular magnetic resonance imaging (CMR)

“…Jest jedną z trzech głównych przyczyn HF i najczęstszą przyczyną kwalifikacji chorych do transplantacji. Etiopatogeneza DCM jest bardzo złożona, obejmuje zarówno zaburzenia genetyczne, jak i przyczyny zapalne, autoimmunologiczne, metaboliczne, toksyczne [5,6].…”